The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

Daniel Tong; Anastasia Constantinidou; Bodil Engelmann; Florence Chamberlain; Khin Thway; Cyril Fisher; Andrew Hayes; Nicos Fotiadis; Christina Messiou; Aisha B Miah; Shane H Zaidi; Charlotte Benson; Winette VAN DER Graaf; Robin L Jones

doi:10.21873/anticanres.13675

The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

Daniel Tong, Anastasia Constantinidou, Bodil Engelmann, Florence Chamberlain, Khin Thway, Cyril Fisher, Andrew Hayes, Nicos Fotiadis, Christina Messiou, Aisha B Miah, Shane H Zaidi, Charlotte Benson, Winette VAN DER Graaf, Robin L Jones

Abstract

BACKGROUND/AIM: Epithelioid haemangioendothelioma (EHE) is a rare tumor with a wide spectrum of clinical behavior. There is no consensus on the role of local therapy in symptomatic, multi-focal disease.

PATIENTS AND METHODS: A retrospective review of patients presenting to the Royal Marsden Hospital between January 2000 and December 2017 was conducted.

RESULTS: Fifty-three patients with EHE were identified, of which 18 patients (34.0%) received local therapy, and 11 patients (20.8%) underwent active surveillance. A variety of local treatment modalities were used with few toxicities, and local recurrence was managed with other local treatments or systemic therapy. Distal disease progression was infrequent (n=4, 7.5%). Patients who developed pleural effusion (n=5, 9.4%) had poor outcome irrespective of treatment.

CONCLUSION: Local therapy has a role in a selected patient group managed in a multidisciplinary setting, including patients with indolent disease, and patients with a solitary area of progression/symptomatic disease.

Originalsprog	Engelsk
Tidsskrift	Anticancer Research
Vol/bind	39
Udgave nummer	9
Sider (fra-til)	4891-4896
Antal sider	6
ISSN	0250-7005
DOI	https://doi.org/10.21873/anticanres.13675
Status	Udgivet - sep. 2019
Udgivet eksternt	Ja

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10.21873/anticanres.13675

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title = "The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma",

abstract = "BACKGROUND/AIM: Epithelioid haemangioendothelioma (EHE) is a rare tumor with a wide spectrum of clinical behavior. There is no consensus on the role of local therapy in symptomatic, multi-focal disease.PATIENTS AND METHODS: A retrospective review of patients presenting to the Royal Marsden Hospital between January 2000 and December 2017 was conducted.RESULTS: Fifty-three patients with EHE were identified, of which 18 patients (34.0%) received local therapy, and 11 patients (20.8%) underwent active surveillance. A variety of local treatment modalities were used with few toxicities, and local recurrence was managed with other local treatments or systemic therapy. Distal disease progression was infrequent (n=4, 7.5%). Patients who developed pleural effusion (n=5, 9.4%) had poor outcome irrespective of treatment.CONCLUSION: Local therapy has a role in a selected patient group managed in a multidisciplinary setting, including patients with indolent disease, and patients with a solitary area of progression/symptomatic disease.",

keywords = "Adolescent, Adult, Aged, Combined Modality Therapy, Disease Management, Female, Hemangioendothelioma, Epithelioid/mortality, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Neoplasm Staging, Pleural Effusion/pathology, Prognosis, Watchful Waiting, Young Adult",

author = "Daniel Tong and Anastasia Constantinidou and Bodil Engelmann and Florence Chamberlain and Khin Thway and Cyril Fisher and Andrew Hayes and Nicos Fotiadis and Christina Messiou and Miah, {Aisha B} and Zaidi, {Shane H} and Charlotte Benson and {VAN DER Graaf}, Winette and Jones, {Robin L}",

year = "2019",

month = sep,

doi = "10.21873/anticanres.13675",

language = "English",

volume = "39",

pages = "4891--4896",

journal = "Anticancer Research",

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TY - JOUR

T1 - The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

AU - Tong, Daniel

AU - Constantinidou, Anastasia

AU - Engelmann, Bodil

AU - Chamberlain, Florence

AU - Thway, Khin

AU - Fisher, Cyril

AU - Hayes, Andrew

AU - Fotiadis, Nicos

AU - Messiou, Christina

AU - Miah, Aisha B

AU - Zaidi, Shane H

AU - Benson, Charlotte

AU - VAN DER Graaf, Winette

AU - Jones, Robin L

PY - 2019/9

Y1 - 2019/9

N2 - BACKGROUND/AIM: Epithelioid haemangioendothelioma (EHE) is a rare tumor with a wide spectrum of clinical behavior. There is no consensus on the role of local therapy in symptomatic, multi-focal disease.PATIENTS AND METHODS: A retrospective review of patients presenting to the Royal Marsden Hospital between January 2000 and December 2017 was conducted.RESULTS: Fifty-three patients with EHE were identified, of which 18 patients (34.0%) received local therapy, and 11 patients (20.8%) underwent active surveillance. A variety of local treatment modalities were used with few toxicities, and local recurrence was managed with other local treatments or systemic therapy. Distal disease progression was infrequent (n=4, 7.5%). Patients who developed pleural effusion (n=5, 9.4%) had poor outcome irrespective of treatment.CONCLUSION: Local therapy has a role in a selected patient group managed in a multidisciplinary setting, including patients with indolent disease, and patients with a solitary area of progression/symptomatic disease.

AB - BACKGROUND/AIM: Epithelioid haemangioendothelioma (EHE) is a rare tumor with a wide spectrum of clinical behavior. There is no consensus on the role of local therapy in symptomatic, multi-focal disease.PATIENTS AND METHODS: A retrospective review of patients presenting to the Royal Marsden Hospital between January 2000 and December 2017 was conducted.RESULTS: Fifty-three patients with EHE were identified, of which 18 patients (34.0%) received local therapy, and 11 patients (20.8%) underwent active surveillance. A variety of local treatment modalities were used with few toxicities, and local recurrence was managed with other local treatments or systemic therapy. Distal disease progression was infrequent (n=4, 7.5%). Patients who developed pleural effusion (n=5, 9.4%) had poor outcome irrespective of treatment.CONCLUSION: Local therapy has a role in a selected patient group managed in a multidisciplinary setting, including patients with indolent disease, and patients with a solitary area of progression/symptomatic disease.

KW - Adolescent

KW - Adult

KW - Aged

KW - Combined Modality Therapy

KW - Disease Management

KW - Female

KW - Hemangioendothelioma, Epithelioid/mortality

KW - Humans

KW - Male

KW - Middle Aged

KW - Neoplasm Recurrence, Local

KW - Neoplasm Staging

KW - Pleural Effusion/pathology

KW - Prognosis

KW - Watchful Waiting

KW - Young Adult

U2 - 10.21873/anticanres.13675

DO - 10.21873/anticanres.13675

M3 - Journal article

C2 - 31519592

SN - 0250-7005

VL - 39

SP - 4891

EP - 4896

JO - Anticancer Research

JF - Anticancer Research

IS - 9

ER -

The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

Abstract

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