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The role of interleukin-1β in the immune response to contact allergens

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

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Vis graf over relationer

Interleukin-1β (IL-1β) is an important pro-inflammatory cytokine that has an effect on almost every cell lineage in the body. By blocking IL-1β and investigating the IL-1β signaling pathway, several studies have demonstrated a central role of IL-1β in the response to contact allergens. This review summarizes the current literature regarding the basic immunological mechanisms mediated by IL-1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL-1β-targeted treatment options, which in the future may be relevant in the treatment of patients with ACD. This review is based primarily on studies using various mouse models and human in vitro studies, since clinical studies on the effect of IL-1β in ACD are lacking.

OriginalsprogEngelsk
TidsskriftContact Dermatitis
Vol/bind85
Udgave nummer4
Sider (fra-til)387-397
Antal sider11
ISSN0105-1873
DOI
StatusUdgivet - okt. 2021

Bibliografisk note

Funding Information:
The LEO Foundation provided an unrestricted grant for the salaries of PhD students Kelvin Yeung and Veronika Mraz. The LEO Foundation has no influence on this review. The research conducted in the center is fully independent of the LEO Foundation. Kelvin Yeung: Conceptualization; visualization; writing-original draft; writing-review & editing. Veronika Mraz: visualization; writing-review & editing. Carsten Geisler: Conceptualization; supervision; writing-review & editing. Lone Skov: Conceptualization; supervision; writing-review & editing. Charlotte M. Bonefeld: Conceptualization; supervision; writing-review & editing.

Publisher Copyright:
© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

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