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The role of infectious agents in cancer of the ocular region

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@article{f10a33adc571459eaa39696178646ccf,
title = "The role of infectious agents in cancer of the ocular region",
abstract = "The purpose of the study was to investigate the association between infectious agents and the development of cancer in the ocular adnexa. A comprehensive literary study was carried out, reviewing and summarizing previous reports on the topic. A broad range of malignancies of the ocular adnexa are associated with infectious agents. A strong association and possible causal relationship between the infectious agent and the development of ocular adnexal cancer are seen in Merkel cell carcinoma (Merkel cell polyomavirus), Burkitt lymphoma (Epstein-Barr virus) and Kaposi sarcoma (human herpesvirus 8). Infection with Chlamydia psittaci has been associated with the development of extranodal marginal zone B-cell lymphoma in Italy. Human papillomavirus infection has been associated with the development of squamous cell carcinomas of the ocular adnexa, although with a highly variable reported prevalence. By exploring the role of infectious agents in the ocular adnexa and the mechanism by which they contribute to oncogenesis, the diagnostics, management and prevention of these malignancies may also improve. Antibiotic treatment and vaccines against infectious agents may be valuable in future treatment. Additionally, the presence of infectious agents within the tumours may have a prognostic or predictive value.",
keywords = "Anti-Bacterial Agents/therapeutic use, Carcinoma, Squamous Cell/drug therapy, Communicable Diseases/complications, Eye Neoplasms/drug therapy, Humans, Italy, infection, human papillomavirus, epstein–barr virus, Merkel cell polyomavirus, Ocular adnexa, human herpes virus 8",
author = "Henriksen, {Josephine Raun} and Ingvild Ramberg and Mikkelsen, {Lauge Hjorth} and Steffen Heegaard",
note = "{\textcopyright} 2020 APMIS. Published by John Wiley & Sons Ltd.",
year = "2020",
month = feb,
doi = "10.1111/apm.13017",
language = "English",
volume = "128",
pages = "136--149",
journal = "APMIS - Journal of Pathology, Microbiology and Immunology",
issn = "0903-4641",
publisher = "Wiley Online",
number = "2",

}

RIS

TY - JOUR

T1 - The role of infectious agents in cancer of the ocular region

AU - Henriksen, Josephine Raun

AU - Ramberg, Ingvild

AU - Mikkelsen, Lauge Hjorth

AU - Heegaard, Steffen

N1 - © 2020 APMIS. Published by John Wiley & Sons Ltd.

PY - 2020/2

Y1 - 2020/2

N2 - The purpose of the study was to investigate the association between infectious agents and the development of cancer in the ocular adnexa. A comprehensive literary study was carried out, reviewing and summarizing previous reports on the topic. A broad range of malignancies of the ocular adnexa are associated with infectious agents. A strong association and possible causal relationship between the infectious agent and the development of ocular adnexal cancer are seen in Merkel cell carcinoma (Merkel cell polyomavirus), Burkitt lymphoma (Epstein-Barr virus) and Kaposi sarcoma (human herpesvirus 8). Infection with Chlamydia psittaci has been associated with the development of extranodal marginal zone B-cell lymphoma in Italy. Human papillomavirus infection has been associated with the development of squamous cell carcinomas of the ocular adnexa, although with a highly variable reported prevalence. By exploring the role of infectious agents in the ocular adnexa and the mechanism by which they contribute to oncogenesis, the diagnostics, management and prevention of these malignancies may also improve. Antibiotic treatment and vaccines against infectious agents may be valuable in future treatment. Additionally, the presence of infectious agents within the tumours may have a prognostic or predictive value.

AB - The purpose of the study was to investigate the association between infectious agents and the development of cancer in the ocular adnexa. A comprehensive literary study was carried out, reviewing and summarizing previous reports on the topic. A broad range of malignancies of the ocular adnexa are associated with infectious agents. A strong association and possible causal relationship between the infectious agent and the development of ocular adnexal cancer are seen in Merkel cell carcinoma (Merkel cell polyomavirus), Burkitt lymphoma (Epstein-Barr virus) and Kaposi sarcoma (human herpesvirus 8). Infection with Chlamydia psittaci has been associated with the development of extranodal marginal zone B-cell lymphoma in Italy. Human papillomavirus infection has been associated with the development of squamous cell carcinomas of the ocular adnexa, although with a highly variable reported prevalence. By exploring the role of infectious agents in the ocular adnexa and the mechanism by which they contribute to oncogenesis, the diagnostics, management and prevention of these malignancies may also improve. Antibiotic treatment and vaccines against infectious agents may be valuable in future treatment. Additionally, the presence of infectious agents within the tumours may have a prognostic or predictive value.

KW - Anti-Bacterial Agents/therapeutic use

KW - Carcinoma, Squamous Cell/drug therapy

KW - Communicable Diseases/complications

KW - Eye Neoplasms/drug therapy

KW - Humans

KW - Italy

KW - infection

KW - human papillomavirus

KW - epstein–barr virus

KW - Merkel cell polyomavirus

KW - Ocular adnexa

KW - human herpes virus 8

UR - http://www.scopus.com/inward/record.url?scp=85078837620&partnerID=8YFLogxK

U2 - 10.1111/apm.13017

DO - 10.1111/apm.13017

M3 - Review

C2 - 32003084

VL - 128

SP - 136

EP - 149

JO - APMIS - Journal of Pathology, Microbiology and Immunology

JF - APMIS - Journal of Pathology, Microbiology and Immunology

SN - 0903-4641

IS - 2

ER -

ID: 61961566