The Role of High-Conductance Calcium Activated Potassium Channel in Headache and Migraine Pathophysiology

Mohammad Al-Mahdi Al-Karagholi*, Cemile Ceren Hakbilen, Messoud Ashina

*Corresponding author af dette arbejde
8 Citationer (Scopus)

Abstract

Migraine is a common, neurovascular headache disorder with a complex molecular interplay. The involvement of ion channels in the pathogenesis of migraine gathered considerable attention with the findings that different ion channels subfamilies are expressed in trigeminovascular system, the physiological substrate of migraine pain, and several ion channel openers investigated in clinical trials with diverse primary endpoints caused headache as a frequent side effect. High-conductance (big) calcium-activated potassium (BKCa ) channel is expressed in the cranial arteries and the trigeminal pain pathway. Recent clinical research revealed that infusion of BKCa channel opener MaxiPost caused vasodilation, headache and migraine attack. Thus, BKCa channel is involved in pathophysiological mechanisms underlying headache and migraine, and targeting BKCa channel presents a new potential strategy for migraine treatment.

OriginalsprogEngelsk
TidsskriftBasic and Clinical Pharmacology and Toxicology
Vol/bind131
Udgave nummer5
Sider (fra-til)347-354
Antal sider8
ISSN1742-7835
DOI
StatusUdgivet - nov. 2022

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