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The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis-Dysregulation by the Liver

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@article{94bea3cddc1d4889a2a70af34f845d61,
title = "The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis-Dysregulation by the Liver",
abstract = "Accumulation of hepatic triacylglycerol (TG) is associated with obesity and metabolic syndrome, which are important pathogenic factors in the development of type 2 diabetes. In this narrative review, we summarize the effects of hepatic TG accumulation on hepatic glucose and insulin metabolism and the underlying molecular regulation in order to highlight the importance of hepatic TG accumulation for whole-body glucose metabolism. We find that liver fat accumulation is closely linked to impaired insulin-mediated suppression of hepatic glucose production and reduced hepatic insulin clearance. The resulting systemic hyperinsulinemia has a major impact on whole-body glucose metabolism and may be an important pathogenic step in the development of type 2 diabetes.",
keywords = "non-alcoholic fatty liver disease (NAFLD), glucose metabolism, insulin resistance, hepatic glucose production, hyperinsulinemic-euglycemic clamp, proton MR spectroscopy, insulin clearance, molecular regulation",
author = "Amalie London and Anne-Marie Lundsgaard and Bente Kiens and Bojsen-M{\o}ller, {Kirstine Nyvold}",
year = "2021",
month = jan,
day = "20",
doi = "10.3390/jcm10030390",
language = "English",
volume = "10",
pages = "1--13",
journal = "Journal of Clinical Medicine",
issn = "2077-0383",
publisher = "M D P I AG",
number = "3",

}

RIS

TY - JOUR

T1 - The Role of Hepatic Fat Accumulation in Glucose and Insulin Homeostasis-Dysregulation by the Liver

AU - London, Amalie

AU - Lundsgaard, Anne-Marie

AU - Kiens, Bente

AU - Bojsen-Møller, Kirstine Nyvold

PY - 2021/1/20

Y1 - 2021/1/20

N2 - Accumulation of hepatic triacylglycerol (TG) is associated with obesity and metabolic syndrome, which are important pathogenic factors in the development of type 2 diabetes. In this narrative review, we summarize the effects of hepatic TG accumulation on hepatic glucose and insulin metabolism and the underlying molecular regulation in order to highlight the importance of hepatic TG accumulation for whole-body glucose metabolism. We find that liver fat accumulation is closely linked to impaired insulin-mediated suppression of hepatic glucose production and reduced hepatic insulin clearance. The resulting systemic hyperinsulinemia has a major impact on whole-body glucose metabolism and may be an important pathogenic step in the development of type 2 diabetes.

AB - Accumulation of hepatic triacylglycerol (TG) is associated with obesity and metabolic syndrome, which are important pathogenic factors in the development of type 2 diabetes. In this narrative review, we summarize the effects of hepatic TG accumulation on hepatic glucose and insulin metabolism and the underlying molecular regulation in order to highlight the importance of hepatic TG accumulation for whole-body glucose metabolism. We find that liver fat accumulation is closely linked to impaired insulin-mediated suppression of hepatic glucose production and reduced hepatic insulin clearance. The resulting systemic hyperinsulinemia has a major impact on whole-body glucose metabolism and may be an important pathogenic step in the development of type 2 diabetes.

KW - non-alcoholic fatty liver disease (NAFLD)

KW - glucose metabolism

KW - insulin resistance

KW - hepatic glucose production

KW - hyperinsulinemic-euglycemic clamp

KW - proton MR spectroscopy

KW - insulin clearance

KW - molecular regulation

U2 - 10.3390/jcm10030390

DO - 10.3390/jcm10030390

M3 - Review

C2 - 33498493

VL - 10

SP - 1

EP - 13

JO - Journal of Clinical Medicine

JF - Journal of Clinical Medicine

SN - 2077-0383

IS - 3

M1 - 390

ER -

ID: 61911158