Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

The role of H1 antihistamines in contralateral breast cancer: a Danish nationwide cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Single-dose intraoperative radiotherapy during lumpectomy for breast cancer: an innovative patient-centred treatment

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  2. CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Breast cancer survival in Nordic BRCA2 mutation carriers-unconventional association with oestrogen receptor status

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Road and railway noise and risk for breast cancer: A nationwide study covering Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Clinical implications of intrinsic molecular subtypes of breast cancer for sentinel node status

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Preclinical studies have shown both pro- and antineoplastic effects of antihistamines. Here, we evaluated the effect of H1 antihistamines on contralateral breast cancer (CBC) risk, and whether cationic amphiphilic (CAD) antihistamines could increase the sensitivity to chemotherapy.

METHODS: From the Danish Breast Cancer Group clinical database, we identified all women aged ≥20 years with a first-time diagnosis of breast cancer during 1996-2012. Information on drug use, CBC and potential confounding factors was retrieved from nationwide registries. Using Cox proportional hazard regression models, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for CBC associated with H1-antihistamine use.

RESULTS: We identified 52,723 patients with breast cancer with a total of 310,583 person-years of follow-up. Among them, 1444 patients developed a new primary tumour in the contralateral breast. Post-diagnosis use of H1 antihistamines (≥2 prescriptions) was not strongly associated with CBC risk (HR 1.08, 95% CI: 0.90-1.31) compared with non-use (<2 prescriptions). Use of CAD antihistamines among patients receiving chemotherapy was not associated with a decrease in CBC risk.

CONCLUSIONS: Taken together, our findings do not suggest any association of H1-antihistamine use with CBC development.

TidsskriftBritish Journal of Cancer
Udgave nummer7
Sider (fra-til)1102-1108
Antal sider7
StatusUdgivet - mar. 2020

ID: 60076739