TY - JOUR
T1 - The risk of schizophrenia and child psychiatric disorders in offspring to mothers with lung cancer and other types of cancer
T2 - a danish nationwide register study
AU - Benros, Michael Eriksen
AU - Laursen, Thomas Munk
AU - Dalton, Susanne Oksbjerg
AU - Nordentoft, Merete
AU - Mortensen, Preben Bo
PY - 2013
Y1 - 2013
N2 - Maternal immune responses and brain-reactive antibodies have been proposed as possible causal mechanisms for schizophrenia and some child psychiatric disorders. According to this hypothesis maternal antibodies may cross the placenta and interact with the developing CNS of the fetus causing future neurodevelopmental disorders. Therefore, we investigated if children of mothers with cancer might be at higher risk of developing psychiatric disorders, with particular focus on small-cell lung cancer, which is known to induce production of antibodies binding to CNS elements.
AB - Maternal immune responses and brain-reactive antibodies have been proposed as possible causal mechanisms for schizophrenia and some child psychiatric disorders. According to this hypothesis maternal antibodies may cross the placenta and interact with the developing CNS of the fetus causing future neurodevelopmental disorders. Therefore, we investigated if children of mothers with cancer might be at higher risk of developing psychiatric disorders, with particular focus on small-cell lung cancer, which is known to induce production of antibodies binding to CNS elements.
U2 - 10.1371/journal.pone.0079031
DO - 10.1371/journal.pone.0079031
M3 - Journal article
C2 - 24223877
SN - 1932-6203
VL - 8
SP - e79031
JO - P L o S One
JF - P L o S One
IS - 11
ER -