TY - JOUR
T1 - The response to treatment of overweight in postmenopausal women is not related to fat distribution
AU - Svendsen, O L
AU - Hassager, C
AU - Christiansen, C
PY - 1995/7
Y1 - 1995/7
N2 - OBJECTIVE: To investigate whether fat distribution or sex hormone status in overweight postmenopausal women do influence the response to treatment of overweight.DESIGN: Longitudinal, clinical intervention study of a 4.2 MJ diet daily with or without exercise.SUBJECTS: 98 healthy, overweight, postmenopausal women (age: 49-58 y, BMI: 25-42 kg/m2).MEASUREMENTS: Various fatness and fat distribution parameters (by dual-energy x-ray absorptiometry and anthropometry), sex hormone-binding globulin (SHBG), sex hormones, and the resting energy expenditure (REE) at baseline and after 3 months.RESULTS: Reductions in weight and fat were independent of the initial fat distribution and the REE, but were significantly associated with high initial SHBG levels. Furthermore, loss of fat was significantly and independently associated with increases in SHBG and reductions in central fat distribution.CONCLUSION: Postmenopausal women with an android and gynoid fat distribution respond with similar weight loss to treatment of overweight. Furthermore, a more healthy, less android, fat distribution and sex hormone status may be achieved with increasing weight loss.
AB - OBJECTIVE: To investigate whether fat distribution or sex hormone status in overweight postmenopausal women do influence the response to treatment of overweight.DESIGN: Longitudinal, clinical intervention study of a 4.2 MJ diet daily with or without exercise.SUBJECTS: 98 healthy, overweight, postmenopausal women (age: 49-58 y, BMI: 25-42 kg/m2).MEASUREMENTS: Various fatness and fat distribution parameters (by dual-energy x-ray absorptiometry and anthropometry), sex hormone-binding globulin (SHBG), sex hormones, and the resting energy expenditure (REE) at baseline and after 3 months.RESULTS: Reductions in weight and fat were independent of the initial fat distribution and the REE, but were significantly associated with high initial SHBG levels. Furthermore, loss of fat was significantly and independently associated with increases in SHBG and reductions in central fat distribution.CONCLUSION: Postmenopausal women with an android and gynoid fat distribution respond with similar weight loss to treatment of overweight. Furthermore, a more healthy, less android, fat distribution and sex hormone status may be achieved with increasing weight loss.
KW - Absorptiometry, Photon
KW - Androstenedione/blood
KW - Anthropometry
KW - Body Composition/physiology
KW - Diet, Reducing/standards
KW - Energy Metabolism/physiology
KW - Estradiol/blood
KW - Exercise/physiology
KW - Female
KW - Gonadal Steroid Hormones/blood
KW - Humans
KW - Longitudinal Studies
KW - Middle Aged
KW - Obesity/metabolism
KW - Postmenopause/physiology
KW - Sex Hormone-Binding Globulin/analysis
KW - Testosterone/blood
M3 - Journal article
C2 - 8520640
VL - 19
SP - 496
EP - 502
JO - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
JF - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity
IS - 7
ER -