@article{a1846be64f334221b794272c2d71f2c8,
title = "The repeatability of interleukin-6, tumor necrosis factor-alpha, and C-reactive protein in COPD patients over one year",
abstract = "BACKGROUND: Many of the systemic manifestations of chronic obstructive pulmonary disease (COPD) are mediated through increased systemic levels of inflammatory proteins. We assessed the long term repeatability of Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) over one year and examined the relationships between these systemic markers in COPD. METHODS: Fifty-eight stable COPD patients completed a baseline and one-year visit. Serum IL-6, plasma CRP, and plasma TNF-alpha were measured. Repeatability was expressed by intraclass correlation coefficient (R(i)) and the Bland-Altman method. Pearson correlations were used to determine the relationships between the systemic markers at both visits. RESULTS: There was moderate repeatability with a very high degree of statistical significance (p",
author = "Umme Kolsum and Kay Roy and Cerys Starkey and Zo{\"e} Borrill and Nick Truman and J{\o}rgen Vestbo and Dave Singh",
year = "2009",
doi = "10.2147/COPD.S5018",
language = "English",
volume = "4",
pages = "149--56",
journal = "International Journal of Chronic Obstructive Pulmonary Disease",
issn = "1176-9106",
publisher = "Dove Medical Press Ltd",
number = "1",
}