The relationship between some beta-adrenergic mediated responses and plasma concentrations of adrenaline and cyclic AMP in man

E K Philipsen, John Gabriel Myhre, S Larsen, M Damkjaer Nielsen, Janett Holst, J Hilsted

6 Citationer (Scopus)

Abstract

To test the hypothesis that increments in plasma cyclic AMP during beta-adrenergic stimulation reflect integrated second messenger function of the tissues activated by the agonist, graded adrenaline infusion resulting in plasma adrenaline concentrations within the physiological range was performed in 8 healthy subjects with and without concomitant beta-adrenoceptor blockade by iv propranolol. A significant correlation was found between increments in plasma adrenaline and plasma cyclic AMP in the experiments without beta-blockade; during concomitant beta-blockade the increase in plasma cyclic AMP concentrations at low adrenaline infusion rates was prevented, whereas a small increase in cyclic AMP was found at high adrenaline infusion rates, probably owing to incomplete beta-receptor blockade. Likewise, the adrenaline-induced increments in blood substrates (glucose, lactate, glycerol and beta hydroxybutyric acid) were significantly reduced but not completely prevented by beta-blockade. We conclude that an altered relationship between beta-agonist concentrations and plasma cyclic AMP may provide evidence for the existence of differences in beta-adrenergic sensitivity in man.
OriginalsprogEngelsk
TidsskriftActa Endocrinologica (Copenh)
Vol/bind122
Udgave nummer1
Sider (fra-til)115-20
Antal sider6
ISSN0001-5598
StatusUdgivet - jan. 1990
Udgivet eksterntJa

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