TY - JOUR
T1 - The relationship between serum potassium concentrations and electrocardiographic characteristics in 163,547 individuals from primary care
AU - Krogager, Maria Lukács
AU - Kragholm, Kristian
AU - Skals, Regitze Kuhr
AU - Mortensen, Rikke Nørmark
AU - Polcwiartek, Christoffer
AU - Graff, Claus
AU - Nielsen, Jonas Bille
AU - Kanters, Jørgen K
AU - Holst, Anders Gaarsdal
AU - Søgaard, Peter
AU - Pietersen, Adrian
AU - Torp-Pedersen, Christian
AU - Hansen, Steen Møller
N1 - Copyright © 2018 Elsevier Inc. All rights reserved.
PY - 2019
Y1 - 2019
N2 - AIMS: Potassium disturbances are common and associated with increased morbidity and mortality, even in patients without prior cardiovascular disease. We examined six electrocardiographic (ECG) measures and their association to serum potassium levels.METHODS AND RESULTS: From the Copenhagen General Practitioners' Laboratory, we identified 163,547 individuals aged ≥16 years with a first available ECG and a concomitant serum potassium measurement during 2001-2011. Restricted cubic splines curves showed a non-linear relationship between potassium and the Fridericia corrected QT (QTcF) interval, T-wave amplitude, morphology combination score (MCS), PR interval, P-wave amplitude and duration. Therefore, potassium was stratified in two intervals K: 2.0-4.1 mmol/L and 4.2-6.0 mmol/L for further analyses. Within the low potassium range, we observed: QTcF was 12.8 ms longer for each mmol/L decrease in potassium (p < 0.0001); T-wave amplitude was 43.1 μV lower for each mmol/L decrease in potassium (p < 0.0001); and MCS was 0.13 higher per mmol/L decrease in potassium (p < 0.001). Moreover, P-wave duration and PR interval were prolonged by 2.7 and 4.6 ms for each mmol/L decrease in potassium (p < 0.0001), respectively. Within the lowest potassium range (2.0-4.1 mmol/L) P-wave amplitude was 3.5 μV higher for each mmol/L decrease in potassium (p < 0.0001). Within the high potassium range associations with the above-mentioned ECG parameters were much weaker.
AB - AIMS: Potassium disturbances are common and associated with increased morbidity and mortality, even in patients without prior cardiovascular disease. We examined six electrocardiographic (ECG) measures and their association to serum potassium levels.METHODS AND RESULTS: From the Copenhagen General Practitioners' Laboratory, we identified 163,547 individuals aged ≥16 years with a first available ECG and a concomitant serum potassium measurement during 2001-2011. Restricted cubic splines curves showed a non-linear relationship between potassium and the Fridericia corrected QT (QTcF) interval, T-wave amplitude, morphology combination score (MCS), PR interval, P-wave amplitude and duration. Therefore, potassium was stratified in two intervals K: 2.0-4.1 mmol/L and 4.2-6.0 mmol/L for further analyses. Within the low potassium range, we observed: QTcF was 12.8 ms longer for each mmol/L decrease in potassium (p < 0.0001); T-wave amplitude was 43.1 μV lower for each mmol/L decrease in potassium (p < 0.0001); and MCS was 0.13 higher per mmol/L decrease in potassium (p < 0.001). Moreover, P-wave duration and PR interval were prolonged by 2.7 and 4.6 ms for each mmol/L decrease in potassium (p < 0.0001), respectively. Within the lowest potassium range (2.0-4.1 mmol/L) P-wave amplitude was 3.5 μV higher for each mmol/L decrease in potassium (p < 0.0001). Within the high potassium range associations with the above-mentioned ECG parameters were much weaker.
KW - ECG
KW - Morphology combination score
KW - P-wave amplitude
KW - P-wave duration
KW - PR interval
KW - QTc interval
KW - Serum potassium
KW - T-wave amplitude
UR - http://www.scopus.com/inward/record.url?scp=85073521183&partnerID=8YFLogxK
U2 - 10.1016/j.jelectrocard.2019.09.005
DO - 10.1016/j.jelectrocard.2019.09.005
M3 - Journal article
C2 - 31629993
VL - 57
SP - 104
EP - 111
JO - Journal of Electrocardiology
JF - Journal of Electrocardiology
SN - 0022-0736
ER -