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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The relation of germ cells per tubule in testes, serum inhibin B and FSH in cryptorchid boys

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The impact of early and successful orchidopexy on hormonal follow-up for 208 boys with bilateral non-syndromic cryptorchidism

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Germ cells positive for PLAP and c-Kit in 11-16 year old normal boys with ongoing spermatogenesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Gonocyte transformation in congenital undescended testes: what is the role of inhibin-B in cell death?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Is infertility after surgery for cryptorchidism congenital or acquired?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. The incidence of maldescended testes in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Fertility Potential is Impaired in Boys with Bilateral Ascending Testes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The impact of early and successful orchidopexy on hormonal follow-up for 208 boys with bilateral non-syndromic cryptorchidism

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Ovarian and Breast Cancer Risks Associated With Pathogenic Variants in RAD51C and RAD51D

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Germ cells positive for PLAP and c-Kit in 11-16 year old normal boys with ongoing spermatogenesis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

At bilateral orchiopexy bilateral biopsies may be indicated to determine fertility potential. It is currently unknown if the serum inhibin B levels at time of orchiopexy reflect the testicular status of the bilaterally cryptorchid child. The aim of this study was to relate the results of inhibin B and FSH measurements with testicular biopsy parameters in bilateral cryptorchid boys. Included were 25 boys with bilateral cryptorchidism, median 2.5 years (9 months to 5.5 years) at surgery for bilateral cryptorchidism with simultaneous testicular biopsies, and blood sample for inhibin B and FSH. The number of spermatogonia and gonocytes was measured in 100 tubular transverse sections, the S/T and the mean-S/T of the patient was found, and expressed as percent of lowest normal value. Inhibin B and FSH were measured and related to age-specific values. Forty percent (10/25) of the patients had very low mean-S/T (mean-S/T<10% of lowest normal-value). Inhibin B was decreased in 24% (6/25) of the patients, all with decreased mean-S/T, predominantly with a mean-S/T<10% of lowest normal-value (p<0.05). There was a negative correlation between inhibin B and FSH (p<0.05). In cases of mean-S/T<10% of lowest normal-value and decreased inhibin B, we found increased FSH in 9% (2/22) of the patients and hypergonadotropic hypogonadism was suspected. Low FSH was found in 5% (1/22) of the patients and hypogonadotropic hypogonadism was suspected. Low inhibin B predicts a serious condition in respect of infertility. Low FSH and inhibin B indicates examination for hypogonadotropic hypogonadism. In bilateral cryptorchid boys inhibin B levels correlated negatively to FSH.

OriginalsprogEngelsk
TidsskriftPediatric Surgery International
Vol/bind23
Udgave nummer2
Sider (fra-til)163-9
Antal sider7
ISSN0179-0358
DOI
StatusUdgivet - feb. 2007

ID: 46508988