Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The Ramazzini Institute 13-week pilot study glyphosate-based herbicides administered at human-equivalent dose to Sprague Dawley rats: effects on development and endocrine system

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Maternal phthalate exposure and asthma, rhinitis and eczema in 552 children aged 5 years; A prospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Impacts of food contact chemicals on human health: a consensus statement

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cardiovascular health effects following exposure of human volunteers during fire extinction exercises

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Prenatal exposure to antifungal medication may change anogenital distance in male offspring: a preliminary study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. No central action of CGRP antagonising drugs in the GTN mouse model of migraine

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Von Frey testing revisited - provision of an online algorithm for improved accuracy of 50% thresholds

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. ATP sensitive potassium (KATP) channel inhibition: A promising new drug target for migraine

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Characterisation and localisation of the endocannabinoid system components in the adult human testis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Fabiana Manservisi
  • Corina Lesseur
  • Simona Panzacchi
  • Daniele Mandrioli
  • Laura Falcioni
  • Luciano Bua
  • Marco Manservigi
  • Marcella Spinaci
  • Giovanna Galeati
  • Alberto Mantovani
  • Stefano Lorenzetti
  • Rossella Miglio
  • Anderson Martino Andrade
  • David Møbjerg Kristensen
  • Melissa J Perry
  • Shanna H Swan
  • Jia Chen
  • Fiorella Belpoggi
Vis graf over relationer

BACKGROUND: Glyphosate-based herbicides (GBHs) are broad-spectrum herbicides that act on the shikimate pathway in bacteria, fungi, and plants. The possible effects of GBHs on human health are the subject of an intense public debate for both its potential carcinogenic and non-carcinogenic effects, including potential effects on the endocrine system The present pilot study examine whether exposure to GBHs at the dose of glyphosate considered to be "safe" (the US Acceptable Daily Intake - ADI - of 1.75 mg/kg bw/day), starting from in utero life, affect the development and endocrine system across different life stages in Sprague Dawley (SD) rats.

METHODS: Glyphosate alone and Roundup Bioflow, a commercial brand of GBHs, were administered in drinking water at 1.75 mg/kg bw/day to F0 dams starting from the gestational day (GD) 6 (in utero) up to postnatal day (PND) 120. After weaning, offspring were randomly distributed in two cohorts: 8 M + 8F/group animals belonging to the 6-week cohort were sacrificed after puberty at PND 73 ± 2; 10 M + 10F/group animals belonging to the 13-week cohort were sacrificed at adulthood at PND 125 ± 2. Effects of glyphosate or Roundup exposure were assessed on developmental landmarks and sexual characteristics of pups.

RESULTS: In pups, anogenital distance (AGD) at PND 4 was statistically significantly increased both in Roundup-treated males and females and in glyphosate-treated males. Age at first estrous (FE) was significantly delayed in the Roundup-exposed group and serum testosterone concentration significantly increased in Roundup-treated female offspring from the 13-week cohort compared to control animals. A statistically significant increase in plasma TSH concentration was observed in glyphosate-treated males compared with control animals as well as a statistically significant decrease in DHT and increase in BDNF in Roundup-treated males. Hormonal status imbalances were more pronounced in Roundup-treated rats after prolonged exposure.

CONCLUSIONS: The present pilot study demonstrate that GBHs exposure, from prenatal period to adulthood, induced endocrine effects and altered reproductive developmental parameters in male and female SD rats. In particular, it was associated with androgen-like effects, including a statistically significant increase of AGDs in both males and females, delay of FE and increased testosterone in female.

OriginalsprogEngelsk
TidsskriftEnvironmental Health: A Global Access Science Source
Vol/bind18
Udgave nummer1
Sider (fra-til)15
ISSN1476-069X
DOI
StatusUdgivet - 2019

ID: 58955533