@article{c46b74feb5be47fbacb1b0979a2b54f3,
title = "The PTPN22 C1858T gene variant is associated with proinsulin in new-onset type 1 diabetes",
abstract = "The protein tyrosine phosphatase nonreceptor type 2 (PTPN22) has been established as a type 1 diabetes susceptibility gene. A recent study found the C1858T variant of this gene to be associated with lower residual fasting C-peptide levels and poorer glycemic control in patients with type 1 diabetes. We investigated the association of the C1858T variant with residual beta-cell function (as assessed by stimulated C-peptide, proinsulin and insulin dose-adjusted HbA1c), glycemic control, daily insulin requirements, diabetic ketoacidosis (DKA) and diabetes-related autoantibodies (IA-2A, GADA, ICA, ZnT8Ab) in children during the first year after diagnosis of type 1 diabetes.",
keywords = "Autoantibodies, C-Peptide, Child, Cohort Studies, Diabetes Mellitus, Type 1, Diabetic Ketoacidosis, Enzyme-Linked Immunosorbent Assay, Female, Genetic Predisposition to Disease, Humans, Male, Polymorphism, Single Nucleotide, Proinsulin, Protein Tyrosine Phosphatase, Non-Receptor Type 22, Regression Analysis, Time Factors",
author = "Nielsen, {Lotte B} and Sven P{\"o}rksen and Andersen, {Marie Louise M} and Siri Fredheim and Jannet Svensson and Philip Hougaard and Maurizio Vanelli and Jan {\AA}man and Mortensen, {Henrik B} and Lars Hansen and {Hvidoere Study Group on Childhood Diabetes}",
year = "2011",
doi = "10.1186/1471-2350-12-41",
language = "English",
volume = "12",
pages = "41",
journal = "B M C Medical Genetics",
issn = "1471-2350",
publisher = "BioMed Central Ltd",
}