The pro-inflammatory effect of uraemia overrules the anti-atherogenic potential of immunization with oxidized LDL in apoE-/- mice

Tanja Xenia Pedersen; Christoph J Binder; Gunilla N Fredrikson; Jan Nilsson; Susanne Bro; Lars B Nielsen

doi:10.1093/ndt/gfq059

The pro-inflammatory effect of uraemia overrules the anti-atherogenic potential of immunization with oxidized LDL in apoE-/- mice

Tanja Xenia Pedersen, Christoph J Binder, Gunilla N Fredrikson, Jan Nilsson, Susanne Bro, Lars B Nielsen

Afdeling for Klinisk Biokemi DIA

4 Citationer (Scopus)

Abstract

Uraemia increases oxidative stress, plasma titres of antibodies recognizing oxidized low-density lipoprotein (oxLDL) and development of atherosclerosis. Immunization with oxLDL prevents classical, non-uraemic atherosclerosis. We have investigated whether immunization with oxLDL might also prevent uraemia-induced atherosclerosis in apolipoprotein E knockout (apoE-/-) mice.

Originalsprog	Engelsk
Tidsskrift	Nephrology, Dialysis, Transplantation
Vol/bind	25
Udgave nummer	8
Sider (fra-til)	2486-91
Antal sider	6
ISSN	0931-0509
DOI	https://doi.org/10.1093/ndt/gfq059
Status	Udgivet - 1 aug. 2010

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The pro-inflammatory effect of uraemia overrules the anti-atherogenic potential of immunization with oxidized LDL in apoE-/- mice. / Pedersen, Tanja Xenia; Binder, Christoph J; Fredrikson, Gunilla N et al.
I: Nephrology, Dialysis, Transplantation, Bind 25, Nr. 8, 01.08.2010, s. 2486-91.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "Uraemia increases oxidative stress, plasma titres of antibodies recognizing oxidized low-density lipoprotein (oxLDL) and development of atherosclerosis. Immunization with oxLDL prevents classical, non-uraemic atherosclerosis. We have investigated whether immunization with oxLDL might also prevent uraemia-induced atherosclerosis in apolipoprotein E knockout (apoE-/-) mice.",

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AU - Pedersen, Tanja Xenia

AU - Binder, Christoph J

AU - Fredrikson, Gunilla N

AU - Nilsson, Jan

AU - Bro, Susanne

AU - Nielsen, Lars B

PY - 2010/8/1

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N2 - Uraemia increases oxidative stress, plasma titres of antibodies recognizing oxidized low-density lipoprotein (oxLDL) and development of atherosclerosis. Immunization with oxLDL prevents classical, non-uraemic atherosclerosis. We have investigated whether immunization with oxLDL might also prevent uraemia-induced atherosclerosis in apolipoprotein E knockout (apoE-/-) mice.

AB - Uraemia increases oxidative stress, plasma titres of antibodies recognizing oxidized low-density lipoprotein (oxLDL) and development of atherosclerosis. Immunization with oxLDL prevents classical, non-uraemic atherosclerosis. We have investigated whether immunization with oxLDL might also prevent uraemia-induced atherosclerosis in apolipoprotein E knockout (apoE-/-) mice.

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IS - 8

ER -

The pro-inflammatory effect of uraemia overrules the anti-atherogenic potential of immunization with oxidized LDL in apoE-/- mice

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