The pro-inflammatory effect of uraemia overrules the anti-atherogenic potential of immunization with oxidized LDL in apoE-/- mice

Tanja Xenia Pedersen, Christoph J Binder, Gunilla N Fredrikson, Jan Nilsson, Susanne Bro, Lars B Nielsen

4 Citationer (Scopus)

Abstract

Uraemia increases oxidative stress, plasma titres of antibodies recognizing oxidized low-density lipoprotein (oxLDL) and development of atherosclerosis. Immunization with oxLDL prevents classical, non-uraemic atherosclerosis. We have investigated whether immunization with oxLDL might also prevent uraemia-induced atherosclerosis in apolipoprotein E knockout (apoE-/-) mice.
OriginalsprogEngelsk
TidsskriftNephrology, Dialysis, Transplantation
Vol/bind25
Udgave nummer8
Sider (fra-til)2486-91
Antal sider6
ISSN0931-0509
DOI
StatusUdgivet - 1 aug. 2010

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