The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study

Harvey O Coxson; Asger Dirksen; Lisa D Edwards; Julie C Yates; Alvar Agusti; Per Bakke; Peter Ma Calverley; Bartolome Celli; Courtney Crim; Annelyse Duvoix; Paola Nasute Fauerbach; David A Lomas; William Macnee; Ruth J Mayer; Bruce E Miller; Nestor L Müller; Stephen I Rennard; Edwin K Silverman; Ruth Tal-Singer; Emiel Fm Wouters; Jørgen Vestbo; Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators

doi:10.1016/S2213-2600(13)70006-7

The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study

Harvey O Coxson, Asger Dirksen, Lisa D Edwards, Julie C Yates, Alvar Agusti, Per Bakke, Peter Ma Calverley, Bartolome Celli, Courtney Crim, Annelyse Duvoix, Paola Nasute Fauerbach, David A Lomas, William Macnee, Ruth J Mayer, Bruce E Miller, Nestor L Müller, Stephen I Rennard, Edwin K Silverman, Ruth Tal-Singer, Emiel Fm WoutersJørgen Vestbo, Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators

213 Citationer (Scopus)

Abstract

Emphysema is a key contributor to airflow limitation in chronic obstructive pulmonary disease (COPD) and can be quantified using CT scanning. We investigated the change in CT lung density in a longitudinal, international cohort of patients with COPD. We also explored the potential relation between emphysema and patient characteristics, and investigated if certain circulating biomarkers were associated with decline in CT lung density.

Originalsprog	Engelsk
Tidsskrift	The Lancet Respiratory Medicine
Vol/bind	1
Udgave nummer	2
Sider (fra-til)	129-36
Antal sider	8
ISSN	2213-2600
DOI	https://doi.org/10.1016/S2213-2600(13)70006-7
Status	Udgivet - apr. 2013

Adgang til dokumentet

10.1016/S2213-2600(13)70006-7

Citationsformater

Coxson, H. O., Dirksen, A., Edwards, L. D., Yates, J. C., Agusti, A., Bakke, P., Calverley, P. M., Celli, B., Crim, C., Duvoix, A., Fauerbach, P. N., Lomas, D. A., Macnee, W., Mayer, R. J., Miller, B. E., Müller, N. L., Rennard, S. I., Silverman, E. K., Tal-Singer, R., ... Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators (2013). The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study. The Lancet Respiratory Medicine, 1(2), 129-36. https://doi.org/10.1016/S2213-2600(13)70006-7

Coxson, HO, Dirksen, A, Edwards, LD, Yates, JC, Agusti, A, Bakke, P, Calverley, PM, Celli, B, Crim, C, Duvoix, A, Fauerbach, PN, Lomas, DA, Macnee, W, Mayer, RJ, Miller, BE, Müller, NL, Rennard, SI, Silverman, EK, Tal-Singer, R, Wouters, EF, Vestbo, J & Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators 2013, 'The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study', The Lancet Respiratory Medicine, bind 1, nr. 2, s. 129-36. https://doi.org/10.1016/S2213-2600(13)70006-7

@article{dfe8e507cea54e5c8dbfe07841d51226,

title = "The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study",

abstract = "Emphysema is a key contributor to airflow limitation in chronic obstructive pulmonary disease (COPD) and can be quantified using CT scanning. We investigated the change in CT lung density in a longitudinal, international cohort of patients with COPD. We also explored the potential relation between emphysema and patient characteristics, and investigated if certain circulating biomarkers were associated with decline in CT lung density.",

author = "Coxson, {Harvey O} and Asger Dirksen and Edwards, {Lisa D} and Yates, {Julie C} and Alvar Agusti and Per Bakke and Calverley, {Peter Ma} and Bartolome Celli and Courtney Crim and Annelyse Duvoix and Fauerbach, {Paola Nasute} and Lomas, {David A} and William Macnee and Mayer, {Ruth J} and Miller, {Bruce E} and M{\"u}ller, {Nestor L} and Rennard, {Stephen I} and Silverman, {Edwin K} and Ruth Tal-Singer and Wouters, {Emiel Fm} and J{\o}rgen Vestbo and {Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators}",

year = "2013",

month = apr,

doi = "10.1016/S2213-2600(13)70006-7",

language = "English",

volume = "1",

pages = "129--36",

journal = "The Lancet Respiratory Medicine",

issn = "2213-2600",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression

T2 - a prospective analysis from the ECLIPSE study

AU - Coxson, Harvey O

AU - Dirksen, Asger

AU - Edwards, Lisa D

AU - Yates, Julie C

AU - Agusti, Alvar

AU - Bakke, Per

AU - Calverley, Peter Ma

AU - Celli, Bartolome

AU - Crim, Courtney

AU - Duvoix, Annelyse

AU - Fauerbach, Paola Nasute

AU - Lomas, David A

AU - Macnee, William

AU - Mayer, Ruth J

AU - Miller, Bruce E

AU - Müller, Nestor L

AU - Rennard, Stephen I

AU - Silverman, Edwin K

AU - Tal-Singer, Ruth

AU - Wouters, Emiel Fm

AU - Vestbo, Jørgen

AU - Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators

PY - 2013/4

Y1 - 2013/4

N2 - Emphysema is a key contributor to airflow limitation in chronic obstructive pulmonary disease (COPD) and can be quantified using CT scanning. We investigated the change in CT lung density in a longitudinal, international cohort of patients with COPD. We also explored the potential relation between emphysema and patient characteristics, and investigated if certain circulating biomarkers were associated with decline in CT lung density.

AB - Emphysema is a key contributor to airflow limitation in chronic obstructive pulmonary disease (COPD) and can be quantified using CT scanning. We investigated the change in CT lung density in a longitudinal, international cohort of patients with COPD. We also explored the potential relation between emphysema and patient characteristics, and investigated if certain circulating biomarkers were associated with decline in CT lung density.

U2 - 10.1016/S2213-2600(13)70006-7

DO - 10.1016/S2213-2600(13)70006-7

M3 - Journal article

C2 - 24429093

VL - 1

SP - 129

EP - 136

JO - The Lancet Respiratory Medicine

JF - The Lancet Respiratory Medicine

SN - 2213-2600

IS - 2

ER -

The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater