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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The pathogenesis of cryptorchidism and splenogonadal fusion: a new hypothesis

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  1. Validation of the self-administered Danish Prostatic Symptom Score (DAN-PSS-1) system for use in benign prostatic hyperplasia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Laparoscopy in 100 consecutive patients with 128 impalpable testes

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  3. Histology of testicular biopsies taken at operation for bilateral maldescended testes in relation to fertility in adulthood

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Voiding patterns and prevalence of incontinence in women. A questionnaire survey

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Voiding patterns in men evaluated by a questionnaire survey

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Xeno-Free Propagation of Spermatogonial Stem Cells from Infant Boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Propagation of Spermatogonial Stem Cell-Like Cells From Infant Boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Sertoli Cell Number Correlates with Serum Inhibin B in Infant Cryptorchid Boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Successful performance of pediatric renography does not require sedation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Successful paediatric renography does not require sedation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: To obtain new information about the pathogenesis of cryptorchidism.

MATERIALS AND METHODS: Published reports of 111 males with splenogonadal fusion were examined and the presence and type of cryptorchidism and the degree of continuity between the spleen and gonads determined.

RESULTS: Of the 111 cases, 31% had cryptorchidism and of these 59% were bilaterally cryptorchid; 26% and 65% had right and left intra-abdominal testes, respectively. Of those with continuous splenogonadal fusion, 44% had cryptorchidism. Solely cryptorchid cases with splenogonadal fusion had reported bilateral absence of both legs, imperforate anus, spina bifida, diaphragmatic hernia and hypospadias.

CONCLUSION: An hypothesis is proposed that the abnormal development of the diaphragmatic ligaments of the testes may lead to lack of their involution, with consequent cryptorchidism. In the case of splenogonadal fusion, the abnormal ligaments are colonized by splenic cells, possibly because of an abnormal proximity to the splenic anlage, with the resulting abnormal ligament persisting as the splenic cord and thus resulting in cryptorchidism. The basic abnormality may be in the connections of the diaphragmatic ligaments, caused by abnormal midline development in the third to fourth week of gestation.

OriginalsprogEngelsk
TidsskriftBr J Urol
Vol/bind77
Udgave nummer2
Sider (fra-til)285-90
Antal sider6
ISSN0007-1331
StatusUdgivet - feb. 1996

ID: 46506554