The OMERACT Knee Inflammation MRI Scoring System: Validation of quantitative methodologies and tri-compartmental overlays in osteoarthritis

Walter P Maksymowych; Andrew McReynolds; Susanne J Pedersen; Ulrich Weber; Joel Paschke; Stephanie Wichuk; Jacob L Jaremko; Robert G Lambert

doi:10.1016/j.semarthrit.2021.05.014

The OMERACT Knee Inflammation MRI Scoring System: Validation of quantitative methodologies and tri-compartmental overlays in osteoarthritis

Walter P Maksymowych, Andrew McReynolds, Susanne J Pedersen, Ulrich Weber, Joel Paschke, Stephanie Wichuk, Jacob L Jaremko, Robert G Lambert

Afdeling for Rygkirurgi, Led- og Bindevævssygdomme

5 Citationer (Scopus)

Abstract

OBJECTIVE: To validate a revised version of the KIMRISS method for quantification of BML and synovitis-effusion in the knee by comparison with an established method, MOAKS.

METHODS: Novel calibration tools were developed for both methods. We compared reliability for status and change scores of BML and synovitis-effusion on baseline and one-year MRI scans.

RESULTS: Significant increase in both BML and synovitis-effusion was evident using KIMRISS but only for synovitis-effusion using MOAKS. Pre-specified targets for acceptable reliability (≥0.80 and ≥0.70 for status and change scores, respectively) were achieved more frequently for KIMRISS for both BML and synovitis.

CONCLUSION: Per OFISA criteria, KIMRISS should progress to assessment of discrimination.

Originalsprog	Engelsk
Tidsskrift	Seminars in Arthritis and Rheumatism
Vol/bind	51
Udgave nummer	4
Sider (fra-til)	925-928
Antal sider	4
ISSN	0049-0172
DOI	https://doi.org/10.1016/j.semarthrit.2021.05.014
Status	Udgivet - aug. 2021

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Maksymowych, W. P., McReynolds, A., Pedersen, S. J., Weber, U., Paschke, J., Wichuk, S., Jaremko, J. L., & Lambert, R. G. (2021). The OMERACT Knee Inflammation MRI Scoring System: Validation of quantitative methodologies and tri-compartmental overlays in osteoarthritis. Seminars in Arthritis and Rheumatism, 51(4), 925-928. https://doi.org/10.1016/j.semarthrit.2021.05.014

The OMERACT Knee Inflammation MRI Scoring System: Validation of quantitative methodologies and tri-compartmental overlays in osteoarthritis. / Maksymowych, Walter P; McReynolds, Andrew; Pedersen, Susanne J et al.
I: Seminars in Arthritis and Rheumatism, Bind 51, Nr. 4, 08.2021, s. 925-928.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "OBJECTIVE: To validate a revised version of the KIMRISS method for quantification of BML and synovitis-effusion in the knee by comparison with an established method, MOAKS.METHODS: Novel calibration tools were developed for both methods. We compared reliability for status and change scores of BML and synovitis-effusion on baseline and one-year MRI scans.RESULTS: Significant increase in both BML and synovitis-effusion was evident using KIMRISS but only for synovitis-effusion using MOAKS. Pre-specified targets for acceptable reliability (≥0.80 and ≥0.70 for status and change scores, respectively) were achieved more frequently for KIMRISS for both BML and synovitis.CONCLUSION: Per OFISA criteria, KIMRISS should progress to assessment of discrimination.",

keywords = "Humans, Inflammation, Magnetic Resonance Imaging, Osteoarthritis, Osteoarthritis, Knee/diagnostic imaging, Reproducibility of Results, Severity of Illness Index, Synovitis/diagnostic imaging",

author = "Maksymowych, {Walter P} and Andrew McReynolds and Pedersen, {Susanne J} and Ulrich Weber and Joel Paschke and Stephanie Wichuk and Jaremko, {Jacob L} and Lambert, {Robert G}",

year = "2021",

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doi = "10.1016/j.semarthrit.2021.05.014",

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AU - Maksymowych, Walter P

AU - McReynolds, Andrew

AU - Pedersen, Susanne J

AU - Weber, Ulrich

AU - Paschke, Joel

AU - Wichuk, Stephanie

AU - Jaremko, Jacob L

AU - Lambert, Robert G

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N2 - OBJECTIVE: To validate a revised version of the KIMRISS method for quantification of BML and synovitis-effusion in the knee by comparison with an established method, MOAKS.METHODS: Novel calibration tools were developed for both methods. We compared reliability for status and change scores of BML and synovitis-effusion on baseline and one-year MRI scans.RESULTS: Significant increase in both BML and synovitis-effusion was evident using KIMRISS but only for synovitis-effusion using MOAKS. Pre-specified targets for acceptable reliability (≥0.80 and ≥0.70 for status and change scores, respectively) were achieved more frequently for KIMRISS for both BML and synovitis.CONCLUSION: Per OFISA criteria, KIMRISS should progress to assessment of discrimination.

AB - OBJECTIVE: To validate a revised version of the KIMRISS method for quantification of BML and synovitis-effusion in the knee by comparison with an established method, MOAKS.METHODS: Novel calibration tools were developed for both methods. We compared reliability for status and change scores of BML and synovitis-effusion on baseline and one-year MRI scans.RESULTS: Significant increase in both BML and synovitis-effusion was evident using KIMRISS but only for synovitis-effusion using MOAKS. Pre-specified targets for acceptable reliability (≥0.80 and ≥0.70 for status and change scores, respectively) were achieved more frequently for KIMRISS for both BML and synovitis.CONCLUSION: Per OFISA criteria, KIMRISS should progress to assessment of discrimination.

KW - Humans

KW - Inflammation

KW - Magnetic Resonance Imaging

KW - Osteoarthritis

KW - Osteoarthritis, Knee/diagnostic imaging

KW - Reproducibility of Results

KW - Severity of Illness Index

KW - Synovitis/diagnostic imaging

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JO - Seminars in Arthritis and Rheumatism

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The OMERACT Knee Inflammation MRI Scoring System: Validation of quantitative methodologies and tri-compartmental overlays in osteoarthritis

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