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Region Hovedstaden - en del af Københavns Universitetshospital
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The neurophenomenology of early psychosis: An integrative empirical study

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  1. Thought insertion and disturbed for-me-ness (minimal selfhood) in schizophrenia

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. The "minimal self" in psychopathology: re-examining the self-disorders in the schizophrenia spectrum

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  3. Is conscious perception gradual or dichotomous? A comparison of report methodologies during a visual task.

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  1. Selbststörungen und Scizophrenie: Eine phänomenologische Neubewetung mangelnder Krankheitseinsicht und Non-Complicance (transl).

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningpeer review

  2. Mental illness among relatives of successful academics: implications for psychopathology-creativity research

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Thought insertion and disturbed for-me-ness (minimal selfhood) in schizophrenia

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Selfhood and its disorders

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningpeer review

  • B Nelson
  • S Lavoie
  • Ł Gawęda
  • E Li
  • L A Sass
  • D Koren
  • P D McGorry
  • B N Jack
  • J Parnas
  • A Polari
  • K Allott
  • J A Hartmann
  • T J Whitford
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BACKGROUND: The integration of various domains or levels of analysis (clinical, neurobiological, genetic, etc.) has been a challenge in schizophrenia research. A promising approach is to use the core phenomenological features of the disorder as an organising principle for other levels of analysis. Minimal self-disturbance (fragility in implicit first-person perspective, presence and agency) is emerging as a strong candidate to play this role. This approach was adopted in a previously described theoretical neurophenomenological model that proposed that source monitoring deficits and aberrant salience may be neurocognitive/neurobiological processes that correlate with minimal self-disturbance on the phenomenological level, together playing an aetiological role in the onset of schizophrenia spectrum disorders. The current paper presents full cross-sectional data from the first empirical test of this model.

METHODS: Fifty ultra-high risk for psychosis patients, 39 first episode psychosis patients and 34 healthy controls were assessed with a variety of clinical measures, including the Examination of Anomalous Self-Experience (EASE), and neurocognitive and neurophysiological (EEG) measures of source monitoring deficits and aberrant salience.

RESULTS: Linear regression indicated that source monitoring (composite score across neurocognitive and neurophysiological measures), with study group as an interaction term, explained 39.8% of the variance in EASE scores (R2 = 0.41, F(3,85) = 14.78, p < 0.001), whereas aberrant salience (composite score) explained only 6% of the variance in EASE scores (R2 = 0.06, F(3,85) = 1.44, p = 0.93). Aberrant salience measures were more strongly related to general psychopathology measures, particularly to positive psychotic symptoms, than to EASE scores.

DISCUSSION: A neurophenomenological model of minimal self-disturbance in schizophrenia spectrum disorders may need to be expanded from source monitoring deficits to encompass other relevant constructs such as temporal processing, intermodal/multisensory integration, and hierarchical predictive processing. The cross-sectional data reported here will be expanded with longitudinal analysis in subsequent reports. These data and other related recent research show an emerging picture of neuro-features of core phenomenological aspects of schizophrenia spectrum disorders beyond surface-level psychotic symptoms.

OriginalsprogEngelsk
TidsskriftConsciousness and Cognition
Vol/bind77
Sider (fra-til)102845
ISSN1053-8100
DOI
StatusUdgivet - jan. 2020

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