The mineralocorticoid receptor antagonist eplerenone reduces renal interstitial fibrosis after long-term cyclosporine treatment in rat: antagonizing cyclosporine nephrotoxicity

Finn Thomsen Nielsen; Linda Boye Jensen; Dorthe Pernille Hansen; Niels Marcussen; Peter Bie

doi:10.1186/1471-2369-14-42

The mineralocorticoid receptor antagonist eplerenone reduces renal interstitial fibrosis after long-term cyclosporine treatment in rat: antagonizing cyclosporine nephrotoxicity

Finn Thomsen Nielsen, Linda Boye Jensen, Dorthe Pernille Hansen, Niels Marcussen, Peter Bie

23 Citationer (Scopus)

Abstract

Chronic cyclosporine-(CsA)-mediated loss of kidney function is a major clinical problem in organ transplantation. We hypothesized that the mineralocorticoid receptor antagonist eplerenone (EPL) prevents chronic CsA-induced renal interstitial volume increase, tubule loss, and functional impairment in a rat model.

Originalsprog	Engelsk
Tidsskrift	B M C Nephrology
Vol/bind	14
Sider (fra-til)	42
ISSN	1471-2369
DOI	https://doi.org/10.1186/1471-2369-14-42
Status	Udgivet - 2013

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10.1186/1471-2369-14-42

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The mineralocorticoid receptor antagonist eplerenone reduces renal interstitial fibrosis after long-term cyclosporine treatment in rat: antagonizing cyclosporine nephrotoxicity. / Nielsen, Finn Thomsen; Jensen, Linda Boye; Hansen, Dorthe Pernille et al.
I: B M C Nephrology, Bind 14, 2013, s. 42.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "Chronic cyclosporine-(CsA)-mediated loss of kidney function is a major clinical problem in organ transplantation. We hypothesized that the mineralocorticoid receptor antagonist eplerenone (EPL) prevents chronic CsA-induced renal interstitial volume increase, tubule loss, and functional impairment in a rat model.",

keywords = "Animals, Cyclosporine, Drug Interactions, Fibrosis, Immunosuppressive Agents, Kidney, Longitudinal Studies, Male, Mineralocorticoid Receptor Antagonists, Nephritis, Interstitial, Rats, Rats, Sprague-Dawley, Spironolactone, Treatment Outcome",

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T2 - antagonizing cyclosporine nephrotoxicity

AU - Nielsen, Finn Thomsen

AU - Jensen, Linda Boye

AU - Hansen, Dorthe Pernille

AU - Marcussen, Niels

AU - Bie, Peter

PY - 2013

Y1 - 2013

N2 - Chronic cyclosporine-(CsA)-mediated loss of kidney function is a major clinical problem in organ transplantation. We hypothesized that the mineralocorticoid receptor antagonist eplerenone (EPL) prevents chronic CsA-induced renal interstitial volume increase, tubule loss, and functional impairment in a rat model.

AB - Chronic cyclosporine-(CsA)-mediated loss of kidney function is a major clinical problem in organ transplantation. We hypothesized that the mineralocorticoid receptor antagonist eplerenone (EPL) prevents chronic CsA-induced renal interstitial volume increase, tubule loss, and functional impairment in a rat model.

KW - Animals

KW - Cyclosporine

KW - Drug Interactions

KW - Fibrosis

KW - Immunosuppressive Agents

KW - Kidney

KW - Longitudinal Studies

KW - Male

KW - Mineralocorticoid Receptor Antagonists

KW - Nephritis, Interstitial

KW - Rats

KW - Rats, Sprague-Dawley

KW - Spironolactone

KW - Treatment Outcome

UR - https://www.scopus.com/pages/publications/84873966799

U2 - 10.1186/1471-2369-14-42

DO - 10.1186/1471-2369-14-42

M3 - Journal article

C2 - 23425330

SN - 1471-2369

VL - 14

SP - 42

JO - B M C Nephrology

JF - B M C Nephrology

ER -

The mineralocorticoid receptor antagonist eplerenone reduces renal interstitial fibrosis after long-term cyclosporine treatment in rat: antagonizing cyclosporine nephrotoxicity

Abstract

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