The mineralocorticoid receptor antagonist eplerenone reduces renal interstitial fibrosis after long-term cyclosporine treatment in rat: antagonizing cyclosporine nephrotoxicity

Finn Thomsen Nielsen, Linda Boye Jensen, Dorthe Pernille Hansen, Niels Marcussen, Peter Bie

    20 Citationer (Scopus)

    Abstract

    Chronic cyclosporine-(CsA)-mediated loss of kidney function is a major clinical problem in organ transplantation. We hypothesized that the mineralocorticoid receptor antagonist eplerenone (EPL) prevents chronic CsA-induced renal interstitial volume increase, tubule loss, and functional impairment in a rat model.
    OriginalsprogEngelsk
    TidsskriftB M C Nephrology
    Vol/bind14
    Sider (fra-til)42
    ISSN1471-2369
    DOI
    StatusUdgivet - 2013

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