@article{23be884ae1db42acbb8890c11e515859,
title = "The mineralocorticoid receptor antagonist eplerenone reduces renal interstitial fibrosis after long-term cyclosporine treatment in rat: antagonizing cyclosporine nephrotoxicity",
abstract = "Chronic cyclosporine-(CsA)-mediated loss of kidney function is a major clinical problem in organ transplantation. We hypothesized that the mineralocorticoid receptor antagonist eplerenone (EPL) prevents chronic CsA-induced renal interstitial volume increase, tubule loss, and functional impairment in a rat model.",
keywords = "Animals, Cyclosporine, Drug Interactions, Fibrosis, Immunosuppressive Agents, Kidney, Longitudinal Studies, Male, Mineralocorticoid Receptor Antagonists, Nephritis, Interstitial, Rats, Rats, Sprague-Dawley, Spironolactone, Treatment Outcome",
author = "Nielsen, {Finn Thomsen} and Jensen, {Linda Boye} and Hansen, {Dorthe Pernille} and Niels Marcussen and Peter Bie",
year = "2013",
doi = "10.1186/1471-2369-14-42",
language = "English",
volume = "14",
pages = "42",
journal = "B M C Nephrology",
issn = "1471-2369",
publisher = "BioMed Central Ltd",
}