The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1

M G A van Eupen; M T Schram; H M Colhoun; N M J Hanssen; H W M Niessen; Lise Tarnow; H H Parving; Pia Rossing; C D A Stehouwer; C G Schalkwijk

doi:10.1007/s00125-013-2919-8

The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1

M G A van Eupen, M T Schram, H M Colhoun, N M J Hanssen, H W M Niessen, Lise Tarnow, H H Parving, Pia Rossing, C D A Stehouwer, C G Schalkwijk

43 Citationer (Scopus)

Abstract

Methylglyoxal (MGO) is a major precursor for advanced glycation end-products (AGEs), which are thought to play a role in vascular complications in diabetes. Known MGO-arginine-derived AGEs are 5-hydro-5-methylimidazolone (MG-H1), argpyrimidine and tetrahydropyrimidine (THP). We studied THP in relation to type 1 diabetes, endothelial dysfunction, low-grade inflammation, vascular complications and atherosclerosis.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	56
Udgave nummer	8
Sider (fra-til)	1845-55
Antal sider	11
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-013-2919-8
Status	Udgivet - aug. 2013

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10.1007/s00125-013-2919-8

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van Eupen, M. G. A., Schram, M. T., Colhoun, H. M., Hanssen, N. M. J., Niessen, H. W. M., Tarnow, L., Parving, H. H., Rossing, P., Stehouwer, C. D. A., & Schalkwijk, C. G. (2013). The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1. Diabetologia, 56(8), 1845-55. https://doi.org/10.1007/s00125-013-2919-8

The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1. / van Eupen, M G A; Schram, M T; Colhoun, H M et al.
I: Diabetologia, Bind 56, Nr. 8, 08.2013, s. 1845-55.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

van Eupen, MGA, Schram, MT, Colhoun, HM, Hanssen, NMJ, Niessen, HWM, Tarnow, L, Parving, HH, Rossing, P, Stehouwer, CDA & Schalkwijk, CG 2013, 'The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1', Diabetologia, bind 56, nr. 8, s. 1845-55. https://doi.org/10.1007/s00125-013-2919-8

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abstract = "Methylglyoxal (MGO) is a major precursor for advanced glycation end-products (AGEs), which are thought to play a role in vascular complications in diabetes. Known MGO-arginine-derived AGEs are 5-hydro-5-methylimidazolone (MG-H1), argpyrimidine and tetrahydropyrimidine (THP). We studied THP in relation to type 1 diabetes, endothelial dysfunction, low-grade inflammation, vascular complications and atherosclerosis.",

author = "{van Eupen}, {M G A} and Schram, {M T} and Colhoun, {H M} and Hanssen, {N M J} and Niessen, {H W M} and Lise Tarnow and Parving, {H H} and Pia Rossing and Stehouwer, {C D A} and Schalkwijk, {C G}",

year = "2013",

month = aug,

doi = "10.1007/s00125-013-2919-8",

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T1 - The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1

AU - van Eupen, M G A

AU - Schram, M T

AU - Colhoun, H M

AU - Hanssen, N M J

AU - Niessen, H W M

AU - Tarnow, Lise

AU - Parving, H H

AU - Rossing, Pia

AU - Stehouwer, C D A

AU - Schalkwijk, C G

PY - 2013/8

Y1 - 2013/8

N2 - Methylglyoxal (MGO) is a major precursor for advanced glycation end-products (AGEs), which are thought to play a role in vascular complications in diabetes. Known MGO-arginine-derived AGEs are 5-hydro-5-methylimidazolone (MG-H1), argpyrimidine and tetrahydropyrimidine (THP). We studied THP in relation to type 1 diabetes, endothelial dysfunction, low-grade inflammation, vascular complications and atherosclerosis.

AB - Methylglyoxal (MGO) is a major precursor for advanced glycation end-products (AGEs), which are thought to play a role in vascular complications in diabetes. Known MGO-arginine-derived AGEs are 5-hydro-5-methylimidazolone (MG-H1), argpyrimidine and tetrahydropyrimidine (THP). We studied THP in relation to type 1 diabetes, endothelial dysfunction, low-grade inflammation, vascular complications and atherosclerosis.

U2 - 10.1007/s00125-013-2919-8

DO - 10.1007/s00125-013-2919-8

M3 - Journal article

C2 - 23620061

SN - 0012-186X

VL - 56

SP - 1845

EP - 1855

JO - Diabetologia

JF - Diabetologia

IS - 8

ER -

The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1

Abstract

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