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The maternal brain: Neural responses to infants in mothers with and without mood disorder

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@article{d650c39c72d34f09af90d1941bc0d6b3,
title = "The maternal brain: Neural responses to infants in mothers with and without mood disorder",
abstract = "Mothers' sensitive responses to their infants have evolutionary importance and are likely hardwired into the maternal brain. Mood disorders are associated with aberrant neural processing of emotion in regions overlapping with 'maternal sensitivity networks' which could compromise maternal processing of infant signals. This systematic review aimed to integrate findings from studies of neural responses to infant stimuli in healthy mothers and in mothers with mood disorders. We included original studies using functional brain imaging and electrophysiological techniques. The databases psycINFO and PubMed were searched for eligible articles until January 2019. Twenty-seven studies met the inclusion criteria, none of which investigated mothers with bipolar disorder or remitted unipolar disorder. Studies were characterized by large methodological heterogeneity. The most consistent findings were that healthy mothers exhibit stronger and faster neural responses to infant stimuli than non-mothers in key emotional processing regions including the amygdala, insula and orbitofrontal cortex, which is accentuated for own infants. Motherswith acute depression display blunted neural responses within these regions which correlates with greater depression severity.",
keywords = "EEG/ERP, fMRI, Infant emotion, Mood disorders, Mother-infant interaction",
author = "Bjertrup, {Anne J} and Friis, {Nellie K} and Miskowiak, {Kamilla W}",
note = "Copyright {\textcopyright} 2019 Elsevier Ltd. All rights reserved.",
year = "2019",
month = dec,
doi = "10.1016/j.neubiorev.2019.09.011",
language = "English",
volume = "107",
pages = "196--207",
journal = "Neuroscience & Biobehavioral Reviews",
issn = "0149-7634",
publisher = "Pergamon",

}

RIS

TY - JOUR

T1 - The maternal brain

T2 - Neural responses to infants in mothers with and without mood disorder

AU - Bjertrup, Anne J

AU - Friis, Nellie K

AU - Miskowiak, Kamilla W

N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.

PY - 2019/12

Y1 - 2019/12

N2 - Mothers' sensitive responses to their infants have evolutionary importance and are likely hardwired into the maternal brain. Mood disorders are associated with aberrant neural processing of emotion in regions overlapping with 'maternal sensitivity networks' which could compromise maternal processing of infant signals. This systematic review aimed to integrate findings from studies of neural responses to infant stimuli in healthy mothers and in mothers with mood disorders. We included original studies using functional brain imaging and electrophysiological techniques. The databases psycINFO and PubMed were searched for eligible articles until January 2019. Twenty-seven studies met the inclusion criteria, none of which investigated mothers with bipolar disorder or remitted unipolar disorder. Studies were characterized by large methodological heterogeneity. The most consistent findings were that healthy mothers exhibit stronger and faster neural responses to infant stimuli than non-mothers in key emotional processing regions including the amygdala, insula and orbitofrontal cortex, which is accentuated for own infants. Motherswith acute depression display blunted neural responses within these regions which correlates with greater depression severity.

AB - Mothers' sensitive responses to their infants have evolutionary importance and are likely hardwired into the maternal brain. Mood disorders are associated with aberrant neural processing of emotion in regions overlapping with 'maternal sensitivity networks' which could compromise maternal processing of infant signals. This systematic review aimed to integrate findings from studies of neural responses to infant stimuli in healthy mothers and in mothers with mood disorders. We included original studies using functional brain imaging and electrophysiological techniques. The databases psycINFO and PubMed were searched for eligible articles until January 2019. Twenty-seven studies met the inclusion criteria, none of which investigated mothers with bipolar disorder or remitted unipolar disorder. Studies were characterized by large methodological heterogeneity. The most consistent findings were that healthy mothers exhibit stronger and faster neural responses to infant stimuli than non-mothers in key emotional processing regions including the amygdala, insula and orbitofrontal cortex, which is accentuated for own infants. Motherswith acute depression display blunted neural responses within these regions which correlates with greater depression severity.

KW - EEG/ERP

KW - fMRI

KW - Infant emotion

KW - Mood disorders

KW - Mother-infant interaction

UR - http://www.scopus.com/inward/record.url?scp=85072242549&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2019.09.011

DO - 10.1016/j.neubiorev.2019.09.011

M3 - Review

C2 - 31518637

VL - 107

SP - 196

EP - 207

JO - Neuroscience & Biobehavioral Reviews

JF - Neuroscience & Biobehavioral Reviews

SN - 0149-7634

ER -

ID: 58079472