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The long-term sequelae of COVID-19: an international consensus on research priorities for patients with pre-existing and new-onset airways disease

Publikation: Bidrag til tidsskriftReviewForskningpeer review

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  • Davies Adeloye
  • Omer Elneima
  • Luke Daines
  • Krisnah Poinasamy
  • Jennifer K Quint
  • Samantha Walker
  • Chris E Brightling
  • Salman Siddiqui
  • John R Hurst
  • James D Chalmers
  • Paul E Pfeffer
  • Petr Novotny
  • Thomas M Drake
  • Liam G Heaney
  • Igor Rudan
  • Aziz Sheikh
  • Anthony De Soyza
  • International COVID-19 Airways Diseases Group
  • Peter Schwarz (Medlem af forfattergruppering)
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Persistent ill health after acute COVID-19-referred to as long COVID, the post-acute COVID-19 syndrome, or the post-COVID-19 condition-has emerged as a major concern. We undertook an international consensus exercise to identify research priorities with the aim of understanding the long-term effects of acute COVID-19, with a focus on people with pre-existing airways disease and the occurrence of new-onset airways disease and associated symptoms. 202 international experts were invited to submit a minimum of three research ideas. After a two-phase internal review process, a final list of 98 research topics was scored by 48 experts. Patients with pre-existing or post-COVID-19 airways disease contributed to the exercise by weighting selected criteria. The highest-ranked research idea focused on investigation of the relationship between prognostic scores at hospital admission and morbidity at 3 months and 12 months after hospital discharge in patients with and without pre-existing airways disease. High priority was also assigned to comparisons of the prevalence and severity of post-COVID-19 fatigue, sarcopenia, anxiety, depression, and risk of future cardiovascular complications in patients with and without pre-existing airways disease. Our approach has enabled development of a set of priorities that could inform future research studies and funding decisions. This prioritisation process could also be adapted to other, non-respiratory aspects of long COVID.

OriginalsprogEngelsk
TidsskriftThe Lancet Respiratory Medicine
Vol/bind9
Udgave nummer12
Sider (fra-til)1467-1478
Antal sider12
ISSN2213-2600
DOI
StatusUdgivet - dec. 2021

Bibliografisk note

Copyright © 2021 Elsevier Ltd. All rights reserved.

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