Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The long-term association between bilateral oophorectomy and depression: a prospective cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Oophorectomy and rate of dementia: a prospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Cardiovascular mortality after bilateral oophorectomy: a prospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Effects of menopause and high-intensity training on insulin sensitivity and muscle metabolism

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Menopause weight gain: the influence of TSEC intervention. the influence of TSEC intervention

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Use of antidepressants and endometrial-cancer risk: a nationwide nested case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Dynamic Changes in LH/FSH Ratios in Infants with Normal Sex Development

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Dynamic changes of reproductive hormones in male minipuberty: Temporal dissociation of Leydig- and Sertoli-cell activity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Oophorectomy and rate of dementia: a prospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: Depression is a leading cause of disability globally and affects more women than men. Ovarian sex steroids are thought to modify depression risk in women and interventions such as bilateral oophorectomy that permanently change the sex steroid milieu may increase the risk of depression. This study aimed to investigate the associations between unilateral and bilateral oophorectomy and depression over a 25-year period (1993-2018) and whether this varied by age at oophorectomy or use of menopausal hormone therapy. METHODS: Twenty-five thousand one hundred eighty-eight nurses aged ≥45 years from the Danish Nurse Cohort were included. Nurses with depression prior to baseline were excluded. Poisson regression models, with log-transformed person-years as offset, were used to assess the associations between oophorectomy and incident depression. Nurses who retained their ovaries were the reference group. RESULTS: Compared with nurses with retained ovaries, bilateral oophorectomy was associated with a slightly higher rate of depression (rate ratio [RR], 1.08; 95% confidence interval [CI], 0.95-1.23), but without statistical significance. However, when stratified by age at oophorectomy, compared with nurses with retained ovaries, bilateral oophorectomy at age ≥51 years was associated with higher rates of depression (RR 1.16; 95% CI, 1.00-1.34), but not bilateral oophorectomy at age <51 years (RR 0.86; 95% CI, 0.69-1.07); P value for difference in estimates = 0.02. No association between unilateral oophorectomy and depression was observed. CONCLUSIONS: In this cohort of Danish female nurses, bilateral oophorectomy at age ≥51 years, but not at younger ages, was associated with a slightly higher rate of depression compared with those who retained their ovaries.

OriginalsprogEngelsk
Artikelnummer0000000000001913
TidsskriftMenopause (New York, N.Y.)
Vol/bind29
Udgave nummer3
Sider (fra-til)276-283
Antal sider8
ISSN1072-3714
DOI
StatusUdgivet - mar. 2022

Bibliografisk note

Copyright © 2022 by The North American Menopause Society.

ID: 75772495