The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine

Mohammad Al-Mahdi Al-Karagholi; Jakob Møller Hansen; Johanne Severinsen; Inger Jansen-Olesen; Messoud Ashina

doi:10.1186/s10194-017-0800-8

The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine

Mohammad Al-Mahdi Al-Karagholi, Jakob Møller Hansen, Johanne Severinsen, Inger Jansen-Olesen, Messoud Ashina

Afdeling for Hjerne- og Nervesygdomme

49 Citationer (Scopus)

Abstract

BACKGROUND: To review the distribution and function of KATP channels, describe the use of KATP channels openers in clinical trials and make the case that these channels may play a role in headache and migraine.

DISCUSSION: KATP channels are widely present in the trigeminovascular system and play an important role in the regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic KATP channel openers report headache as a prevalent-side effect in non-migraine sufferers, indicating that KATP channel opening may cause headache, possibly due to vascular mechanisms. Whether KATP channel openers can provoke migraine in migraine sufferers is not known.

CONCLUSION: We suggest that KATP channels may play an important role in migraine pathogenesis and could be a potential novel therapeutic anti-migraine target.

Originalsprog	Engelsk
Tidsskrift	Journal of Headache and Pain
Vol/bind	18
Udgave nummer	1
Sider (fra-til)	90
ISSN	1129-2369
DOI	https://doi.org/10.1186/s10194-017-0800-8
Status	Udgivet - 23 aug. 2017

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10.1186/s10194-017-0800-8

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AU - Jansen-Olesen, Inger

AU - Ashina, Messoud

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AB - BACKGROUND: To review the distribution and function of KATP channels, describe the use of KATP channels openers in clinical trials and make the case that these channels may play a role in headache and migraine.DISCUSSION: KATP channels are widely present in the trigeminovascular system and play an important role in the regulation of tone in cerebral and meningeal arteries. Clinical trials using synthetic KATP channel openers report headache as a prevalent-side effect in non-migraine sufferers, indicating that KATP channel opening may cause headache, possibly due to vascular mechanisms. Whether KATP channel openers can provoke migraine in migraine sufferers is not known.CONCLUSION: We suggest that KATP channels may play an important role in migraine pathogenesis and could be a potential novel therapeutic anti-migraine target.

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The KATP channel in migraine pathophysiology: a novel therapeutic target for migraine

Abstract

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