The Journey to Establish CGRP as a Migraine Target: A Retrospective View

Lars Edvinsson

doi:10.1111/head.12656

The Journey to Establish CGRP as a Migraine Target: A Retrospective View

46 Citationer (Scopus)

Abstract

In this retrospective, Dr. Lars Edvinsson recounts early steps and milestones in our understanding of the neuropeptide calcitonin gene-related peptide (CGRP) in the trigeminovascular system and its role in migraine. The discovery of the presence and function of CGRP and other neuropeptides in the cerebral vasculature and its sensory innervation is described. He relates the seminal finding that CGRP is uniquely released during migraine and the journey to develop blockers of CGRP effects. Now, over 30 years since its discovery, CGRP has become the target for a number of promising novel treatments for migraine patients.

Originalsprog	Engelsk
Tidsskrift	Headache Online
Vol/bind	55
Udgave nummer	9
Sider (fra-til)	1249-55
ISSN	1526-4610
DOI	https://doi.org/10.1111/head.12656
Status	Udgivet - 14 sep. 2015
Udgivet eksternt	Ja

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10.1111/head.12656

Citationsformater

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AB - In this retrospective, Dr. Lars Edvinsson recounts early steps and milestones in our understanding of the neuropeptide calcitonin gene-related peptide (CGRP) in the trigeminovascular system and its role in migraine. The discovery of the presence and function of CGRP and other neuropeptides in the cerebral vasculature and its sensory innervation is described. He relates the seminal finding that CGRP is uniquely released during migraine and the journey to develop blockers of CGRP effects. Now, over 30 years since its discovery, CGRP has become the target for a number of promising novel treatments for migraine patients.

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The Journey to Establish CGRP as a Migraine Target: A Retrospective View

Abstract

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