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Region Hovedstaden - en del af Københavns Universitetshospital
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The Journey to Establish CGRP as a Migraine Target: A Retrospective View

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  1. Hormonal influences in migraine - interactions of oestrogen, oxytocin and CGRP

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  2. CGRP and migraine; from bench to bedside

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  3. Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

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Vis graf over relationer

In this retrospective, Dr. Lars Edvinsson recounts early steps and milestones in our understanding of the neuropeptide calcitonin gene-related peptide (CGRP) in the trigeminovascular system and its role in migraine. The discovery of the presence and function of CGRP and other neuropeptides in the cerebral vasculature and its sensory innervation is described. He relates the seminal finding that CGRP is uniquely released during migraine and the journey to develop blockers of CGRP effects. Now, over 30 years since its discovery, CGRP has become the target for a number of promising novel treatments for migraine patients.

OriginalsprogEngelsk
TidsskriftHeadache Online
Vol/bind55
Udgave nummer9
Sider (fra-til)1249-55
ISSN1526-4610
DOI
StatusUdgivet - 14 sep. 2015
Eksternt udgivetJa

ID: 45639609