Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The iPSYCH2012 case-cohort sample: new directions for unravelling genetic and environmental architectures of severe mental disorders

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A major role for common genetic variation in anxiety disorders

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Dysregulated Lipid Metabolism Precedes Onset of Psychosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Assessment of Suicidal Behaviors Among Individuals With Autism Spectrum Disorder in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Association between neonatal homecare for preterm infants and incidence of severe postpartum depression in mothers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • C B Pedersen
  • Jonas Bybjerg-Grauholm
  • M G Pedersen
  • Jakob Grove
  • E Agerbo
  • M Bækvad-Hansen
  • J B Poulsen
  • C S Hansen
  • John J McGrath
  • Thomas D Als
  • Jacqueline I Goldstein
  • Benjamin M Neale
  • Mark J Daly
  • D M Hougaard
  • O Mors
  • M Nordentoft
  • A D Børglum
  • T Werge
  • P B Mortensen
Vis graf over relationer

The Integrative Psychiatric Research (iPSYCH) consortium has established a large Danish population-based Case-Cohort sample (iPSYCH2012) aimed at unravelling the genetic and environmental architecture of severe mental disorders. The iPSYCH2012 sample is nested within the entire Danish population born between 1981 and 2005, including 1 472 762 persons. This paper introduces the iPSYCH2012 sample and outlines key future research directions. Cases were identified as persons with schizophrenia (N=3540), autism (N=16 146), attention-deficit/hyperactivity disorder (N=18 726) and affective disorder (N=26 380), of which 1928 had bipolar affective disorder. Controls were randomly sampled individuals (N=30 000). Within the sample of 86 189 individuals, a total of 57 377 individuals had at least one major mental disorder. DNA was extracted from the neonatal dried blood spot samples obtained from the Danish Neonatal Screening Biobank and genotyped using the Illumina PsychChip. Genotyping was successful for 90% of the sample. The assessments of exome sequencing, methylation profiling, metabolome profiling, vitamin-D, inflammatory and neurotrophic factors are in progress. For each individual, the iPSYCH2012 sample also includes longitudinal information on health, prescribed medicine, social and socioeconomic information, and analogous information among relatives. To the best of our knowledge, the iPSYCH2012 sample is the largest and most comprehensive data source for the combined study of genetic and environmental aetiologies of severe mental disorders.Molecular Psychiatry advance online publication, 19 September 2017; doi:10.1038/mp.2017.196.

OriginalsprogEngelsk
TidsskriftMolecular Psychiatry
Vol/bind23
Sider (fra-til)6-14
ISSN1359-4184
DOI
StatusUdgivet - 2018

ID: 51750688