The influence of haematocrit and blood glucose on cerebral blood flow in normal and in diabetic rats

G M Knudsen; E Tedeschi; J Jakobsen

doi:10.1097/00001756-199211000-00010

The influence of haematocrit and blood glucose on cerebral blood flow in normal and in diabetic rats

G M Knudsen, E Tedeschi, J Jakobsen

7 Citationer (Scopus)

Abstract

Cerebral blood flow (CBF) was measured at varying haematocrit values in 8 streptozotocin-diabetic and in 7 control rats using the intracarotid 133Xe technique. A hyperbolic relationship between CBF and haematocrit was established for the individual rats in both groups. Diabetic animals showed a preserved CBF response to changes to haematocrit. In 10 normal rats, CBF was measured during acute hyperglycaemia induced by intraperitoneal glucose injection. A significant, inverse correlation was found between CBF and blood glucose. We conclude that the CBF response to changes in haematocrit and thereby in pO2 is preserved in experimental diabetes. Secondly, in acute hyperglycaemia CBF varies inversely with blood glucose, by mechanisms not fully understood.

Originalsprog	Engelsk
Tidsskrift	NeuroReport
Vol/bind	3
Udgave nummer	11
Sider (fra-til)	987-9
Antal sider	3
ISSN	0959-4965
DOI	https://doi.org/10.1097/00001756-199211000-00010
Status	Udgivet - nov. 1992
Udgivet eksternt	Ja

Adgang til dokumentet

10.1097/00001756-199211000-00010

Citationsformater

@article{5907463155c94e99904f91345f8f11e2,

title = "The influence of haematocrit and blood glucose on cerebral blood flow in normal and in diabetic rats",

abstract = "Cerebral blood flow (CBF) was measured at varying haematocrit values in 8 streptozotocin-diabetic and in 7 control rats using the intracarotid 133Xe technique. A hyperbolic relationship between CBF and haematocrit was established for the individual rats in both groups. Diabetic animals showed a preserved CBF response to changes to haematocrit. In 10 normal rats, CBF was measured during acute hyperglycaemia induced by intraperitoneal glucose injection. A significant, inverse correlation was found between CBF and blood glucose. We conclude that the CBF response to changes in haematocrit and thereby in pO2 is preserved in experimental diabetes. Secondly, in acute hyperglycaemia CBF varies inversely with blood glucose, by mechanisms not fully understood.",

keywords = "Animals, Blood Glucose/physiology, Body Weight/physiology, Cerebrovascular Circulation/physiology, Diabetes Mellitus, Experimental/blood, Hematocrit, Male, Rats, Rats, Wistar, Xenon Radioisotopes",

author = "Knudsen, {G M} and E Tedeschi and J Jakobsen",

year = "1992",

month = nov,

doi = "10.1097/00001756-199211000-00010",

language = "English",

volume = "3",

pages = "987--9",

journal = "NeuroReport",

issn = "0959-4965",

publisher = "Lippincott Williams and Wilkins",

number = "11",

}

TY - JOUR

T1 - The influence of haematocrit and blood glucose on cerebral blood flow in normal and in diabetic rats

AU - Knudsen, G M

AU - Tedeschi, E

AU - Jakobsen, J

PY - 1992/11

Y1 - 1992/11

N2 - Cerebral blood flow (CBF) was measured at varying haematocrit values in 8 streptozotocin-diabetic and in 7 control rats using the intracarotid 133Xe technique. A hyperbolic relationship between CBF and haematocrit was established for the individual rats in both groups. Diabetic animals showed a preserved CBF response to changes to haematocrit. In 10 normal rats, CBF was measured during acute hyperglycaemia induced by intraperitoneal glucose injection. A significant, inverse correlation was found between CBF and blood glucose. We conclude that the CBF response to changes in haematocrit and thereby in pO2 is preserved in experimental diabetes. Secondly, in acute hyperglycaemia CBF varies inversely with blood glucose, by mechanisms not fully understood.

AB - Cerebral blood flow (CBF) was measured at varying haematocrit values in 8 streptozotocin-diabetic and in 7 control rats using the intracarotid 133Xe technique. A hyperbolic relationship between CBF and haematocrit was established for the individual rats in both groups. Diabetic animals showed a preserved CBF response to changes to haematocrit. In 10 normal rats, CBF was measured during acute hyperglycaemia induced by intraperitoneal glucose injection. A significant, inverse correlation was found between CBF and blood glucose. We conclude that the CBF response to changes in haematocrit and thereby in pO2 is preserved in experimental diabetes. Secondly, in acute hyperglycaemia CBF varies inversely with blood glucose, by mechanisms not fully understood.

KW - Animals

KW - Blood Glucose/physiology

KW - Body Weight/physiology

KW - Cerebrovascular Circulation/physiology

KW - Diabetes Mellitus, Experimental/blood

KW - Hematocrit

KW - Male

KW - Rats

KW - Rats, Wistar

KW - Xenon Radioisotopes

U2 - 10.1097/00001756-199211000-00010

DO - 10.1097/00001756-199211000-00010

M3 - Journal article

C2 - 1482770

SN - 0959-4965

VL - 3

SP - 987

EP - 989

JO - NeuroReport

JF - NeuroReport

IS - 11

ER -

The influence of haematocrit and blood glucose on cerebral blood flow in normal and in diabetic rats

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater