Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The Incidence of Free Peritoneal Tumor Cells before and after Neoadjuvant Chemotherapy in Gastroesophageal Junction Cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Diagnostic Value of Processing Cytologic Aspirates of Renal Tumors in Agar Cell (Tissue) Blocks

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Frequency of medical procedures in cytology-based cervical screening: Danish experience

    Publikation: Bidrag til tidsskriftKonferenceartikelForskningpeer review

  1. Acinar cystic transformation of the pancreas: Report of a case and a review of the literature

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Using computerized assessment in simulated colonoscopy: a validation study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Clinical value of serum hyaluronan and propeptide of type III collagen in patients with pancreatic cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Prognostic impact of Charlson's Age-Comorbidity Index and other risk factors in patients with pancreatic cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. A rare missense variant in APC interrupts splicing and causes AFAP in two Danish families

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Context: The utility of peritoneal washing cytology in patients with gastroesophageal junction cancer has not been thoroughly evaluated.

Aims: The study aimed to determine the incidence of free peritoneal tumor cells by peritoneal washing cytology before and after neoadjuvant chemotherapy using conventional cytopathological methods and immunohistochemical staining for the analysis of peritoneal washings.

Settings and Design: A prospective study conducted at a single tertiary referral hospital.

Materials and Methods: Patients with gastroesophageal junction cancer and without suspicion of intra- or extraabdominal metastases before the staging laparoscopy were prospectively and consecutively enrolled. Peritoneal washing cytology was performed at staging laparoscopy (primary cytology) and after neoadjuvant chemotherapy during robot-assisted or open resection (secondary cytology). Peritoneal fluid samples were analyzed by conventional cytology and an immunohistochemical panel.

Results: Overall, 81 patients met the primary inclusion criteria. During primary cytology, positive cytology without overt metastases (C1M0) was detected in three patients (3.8%) while five patients (6.3%) had overt intra-abdominal metastases but negative cytology (C0M1). None of the patients with C1M0 underwent surgery due to extra-abdominal (n = 1) or intra-abdominal metastases (n = 2), and the overall survival was 4, 7, and 14 months. During secondary cytology, no patients with free peritoneal tumor cells were identified, but seven patients were classified as C0M1 (10.9%).

Conclusions: The incidence of C1M0 was 3.8% and 0% before and after neoadjuvant chemotherapy, respectively in patients with gastroesophageal junction cancer. Free peritoneal tumor cells were not identified in several patients with intra-abdominal metastases suggesting that peritoneal washing cytology with conventional cytology and immunohistochemical staining lack sensitivity.

OriginalsprogEngelsk
TidsskriftActa Cytologica
Vol/bind37
Udgave nummer1
Sider (fra-til)40-45
Antal sider6
ISSN0970-9371
DOI
StatusUdgivet - 17 jan. 2020

Bibliografisk note

Copyright: © 2019 Journal of Cytology.

ID: 59212355