Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The incidence of cancer and mortality in paediatric onset inflammatory bowel disease in Denmark and Finland during a 23-year period: a population-based study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. All-cause and cause-specific mortality in microscopic colitis: a Danish nationwide matched cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Fibrogenesis and inflammation contribute to the pathogenesis of cirrhotic cardiomyopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Letter: suicide risk among adult inflammatory bowel disease patients. Authors' reply

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  4. Editorial: suicide and IBD-a call to action. Authors' reply

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  1. Paediatric hepatitis B and hepatitis C virus infections: an observational study of a Danish cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Extraintestinal Manifestations are Associated with Disease Severity in Pediatric Onset Inflammatory Bowel Disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Letter: suicide risk among adult inflammatory bowel disease patients. Authors' reply

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  4. Telemedicin til monitorering af inflammatoriske tarmsygdomme og colon irritabile

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Recent studies report increased risks of both cancer and mortality in paediatric onset inflammatory bowel disease (pIBD) but the reproducibility of this is unknown.

AIM: In this population-based study we aim to estimate the risk of cancer and mortality in the Danish and Finnish pIBD population in a 23-year period compared to the general population.

METHODS: The pIBD population was defined as individuals registered in the national patient registries with a diagnosis of Crohn's disease (CD), ulcerative colitis (UC) or IBD-unclassified before their 18th birthday from 1992 to 2014. This cohort was cross referenced with the national cancer and mortality registries identifying all pIBD patients who subsequently developed cancer and/ or died and followed up to the end of 2014. Risk estimates are presented as standardised incidence ratios calculated based on incidence figures from the populations.

RESULTS: Six thousand six hundred and eight-nine patients with pIBD were identified (median age at follow-up 22.3 years; median follow-up: 9.6 years [interquartile range: 4.8-16.0]). Seventy-two subsequently developed cancer and 65 died. The standardised incidence ratio of cancer in general was 2.6 (95% CI: 1.8-3.7) and 2.5 (95% CI: 1.8-3.4) in CD and UC, respectively. The standardised mortality ratios were 2.2 (95% CI: 1.4-3.4) and 3.7 (95% CI: 2.7-5.0) in CD and UC, respectively. The leading causes for mortality were cancer, suicide and infections.

CONCLUSIONS: We found an increased risk of cancer and mortality in pIBD. This underlines the importance of cancer surveillance programs and assessment of mental health in the standard of care in adolescent pIBD patients.

OriginalsprogEngelsk
TidsskriftAlimentary Pharmacology and Therapeutics
Vol/bind50
Udgave nummer1
Sider (fra-til)33-39
Antal sider7
ISSN0269-2813
DOI
StatusUdgivet - jul. 2019

Bibliografisk note

© 2019 John Wiley & Sons Ltd.

ID: 57120793