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The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

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Harvard

Vrang, N, Meyre, D, Froguel, P, Jelsing, J, Tang-Christensen, M, Vatin, V, Mikkelsen, JD, Thirstrup, K, Larsen, LK, Cullberg, KB, Fahrenkrug, J, Jacobson, P, Sjöström, L, Carlsson, LMS, Liu, Y, Liu, X, Deng, H-W & Larsen, PJ 2010, 'The imprinted gene neuronatin is regulated by metabolic status and associated with obesity', Obesity, bind 18, nr. 7, s. 1289-96. https://doi.org/10.1038/oby.2009.361

APA

Vrang, N., Meyre, D., Froguel, P., Jelsing, J., Tang-Christensen, M., Vatin, V., Mikkelsen, J. D., Thirstrup, K., Larsen, L. K., Cullberg, K. B., Fahrenkrug, J., Jacobson, P., Sjöström, L., Carlsson, L. M. S., Liu, Y., Liu, X., Deng, H-W., & Larsen, P. J. (2010). The imprinted gene neuronatin is regulated by metabolic status and associated with obesity. Obesity, 18(7), 1289-96. https://doi.org/10.1038/oby.2009.361

CBE

Vrang N, Meyre D, Froguel P, Jelsing J, Tang-Christensen M, Vatin V, Mikkelsen JD, Thirstrup K, Larsen LK, Cullberg KB, Fahrenkrug J, Jacobson P, Sjöström L, Carlsson LMS, Liu Y, Liu X, Deng H-W, Larsen PJ. 2010. The imprinted gene neuronatin is regulated by metabolic status and associated with obesity. Obesity. 18(7):1289-96. https://doi.org/10.1038/oby.2009.361

MLA

Vancouver

Vrang N, Meyre D, Froguel P, Jelsing J, Tang-Christensen M, Vatin V o.a. The imprinted gene neuronatin is regulated by metabolic status and associated with obesity. Obesity. 2010 jul 1;18(7):1289-96. https://doi.org/10.1038/oby.2009.361

Author

Vrang, Niels ; Meyre, David ; Froguel, Phillippe ; Jelsing, Jacob ; Tang-Christensen, Mads ; Vatin, Vincent ; Mikkelsen, Jens D ; Thirstrup, Kenneth ; Larsen, Leif K ; Cullberg, Karina B ; Fahrenkrug, Jan ; Jacobson, Per ; Sjöström, Lars ; Carlsson, Lena M S ; Liu, Yongjun ; Liu, Xiaogang ; Deng, Hong-Wen ; Larsen, Philip J. / The imprinted gene neuronatin is regulated by metabolic status and associated with obesity. I: Obesity. 2010 ; Bind 18, Nr. 7. s. 1289-96.

Bibtex

@article{b31aa044e9514022b00fba3161877e20,
title = "The imprinted gene neuronatin is regulated by metabolic status and associated with obesity",
abstract = "Using restriction fragment differential display (RFDD) technology, we have identified the imprinted gene neuronatin (Nnat) as a hypothalamic target under the influence of leptin. Nnat mRNA expression is decreased in several key appetite regulatory hypothalamic nuclei in rodents with impaired leptin signaling and during fasting conditions. Furthermore, peripheral administration of leptin to ob/ob mice normalizes hypothalamic Nnat expression. Comparative immunohistochemical analysis of human and rat hypothalami demonstrates that NNAT protein is present in anatomically equivalent nuclei, suggesting human physiological relevance of the gene product(s). A putative role of Nnat in human energy homeostasis is further emphasized by a consistent association between single nucleotide polymorphisms (SNPs) in the human Nnat gene and severe childhood and adult obesity.",
author = "Niels Vrang and David Meyre and Phillippe Froguel and Jacob Jelsing and Mads Tang-Christensen and Vincent Vatin and Mikkelsen, {Jens D} and Kenneth Thirstrup and Larsen, {Leif K} and Cullberg, {Karina B} and Jan Fahrenkrug and Per Jacobson and Lars Sj{\"o}str{\"o}m and Carlsson, {Lena M S} and Yongjun Liu and Xiaogang Liu and Hong-Wen Deng and Larsen, {Philip J}",
year = "2010",
month = jul,
day = "1",
doi = "10.1038/oby.2009.361",
language = "English",
volume = "18",
pages = "1289--96",
journal = "Obesity",
issn = "1930-7381",
publisher = "Nature Publishing Group",
number = "7",

}

RIS

TY - JOUR

T1 - The imprinted gene neuronatin is regulated by metabolic status and associated with obesity

AU - Vrang, Niels

AU - Meyre, David

AU - Froguel, Phillippe

AU - Jelsing, Jacob

AU - Tang-Christensen, Mads

AU - Vatin, Vincent

AU - Mikkelsen, Jens D

AU - Thirstrup, Kenneth

AU - Larsen, Leif K

AU - Cullberg, Karina B

AU - Fahrenkrug, Jan

AU - Jacobson, Per

AU - Sjöström, Lars

AU - Carlsson, Lena M S

AU - Liu, Yongjun

AU - Liu, Xiaogang

AU - Deng, Hong-Wen

AU - Larsen, Philip J

PY - 2010/7/1

Y1 - 2010/7/1

N2 - Using restriction fragment differential display (RFDD) technology, we have identified the imprinted gene neuronatin (Nnat) as a hypothalamic target under the influence of leptin. Nnat mRNA expression is decreased in several key appetite regulatory hypothalamic nuclei in rodents with impaired leptin signaling and during fasting conditions. Furthermore, peripheral administration of leptin to ob/ob mice normalizes hypothalamic Nnat expression. Comparative immunohistochemical analysis of human and rat hypothalami demonstrates that NNAT protein is present in anatomically equivalent nuclei, suggesting human physiological relevance of the gene product(s). A putative role of Nnat in human energy homeostasis is further emphasized by a consistent association between single nucleotide polymorphisms (SNPs) in the human Nnat gene and severe childhood and adult obesity.

AB - Using restriction fragment differential display (RFDD) technology, we have identified the imprinted gene neuronatin (Nnat) as a hypothalamic target under the influence of leptin. Nnat mRNA expression is decreased in several key appetite regulatory hypothalamic nuclei in rodents with impaired leptin signaling and during fasting conditions. Furthermore, peripheral administration of leptin to ob/ob mice normalizes hypothalamic Nnat expression. Comparative immunohistochemical analysis of human and rat hypothalami demonstrates that NNAT protein is present in anatomically equivalent nuclei, suggesting human physiological relevance of the gene product(s). A putative role of Nnat in human energy homeostasis is further emphasized by a consistent association between single nucleotide polymorphisms (SNPs) in the human Nnat gene and severe childhood and adult obesity.

U2 - 10.1038/oby.2009.361

DO - 10.1038/oby.2009.361

M3 - Journal article

C2 - 19851307

VL - 18

SP - 1289

EP - 1296

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 7

ER -

ID: 32200179