The impact of treatment density and molecular weight for fractional laser-assisted drug delivery

Christina S Haak, Brijesh Bhayana, William A Farinelli, R Rox Anderson, Merete Haedersdal

49 Citationer (Scopus)

Abstract

Ablative fractional lasers (AFXL) facilitate uptake of topically applied drugs by creating narrow open micro-channels into the skin, but there is limited information on optimal laser settings for delivery of specific molecules. The objective of this study was to investigate the impact of laser treatment density (% of skin occupied by channels) and molecular weight (MW) for fractional CO(2) laser-assisted drug delivery. AFXL substantially increased intra- and transcutaneous delivery of polyethylene glycols (PEGs) in a MW range from 240 to 4300 Da (Nuclear Magnetic Resonance, p
OriginalsprogEngelsk
TidsskriftJournal of Controlled Release
Vol/bind163
Udgave nummer3
Sider (fra-til)335-41
Antal sider7
ISSN0168-3659
DOI
StatusUdgivet - 2012

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