Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

The impact of tobacco smoking on survival of patients with oral squamous cell carcinoma: a population-based retrospective study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Drop in cancer diagnosis during the COVID-19 pandemic in Denmark: assessment of impact during 2020

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Severity and 90-day survival of SARS-CoV-2 infection among patients with haematological disorders

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  3. Changing before we have to; how to mitigate disparities in pancreatic cancer care?

    Publikation: Bidrag til tidsskriftLederForskningpeer review

Vis graf over relationer

BACKGROUND: This article aims to evaluate the impact of smoking status, accumulated tobacco exposure (ATE), and smoking cessation on overall- and disease-free survival (OS and DFS) of patients with oral squamous cell carcinoma (OSCC).

MATERIAL AND METHODS: Patients with primary OSCC treated with curative intent between 2000 and 2019 in Copenhagen were included (n = 1808). Kaplan-Meier curves and multivariable Cox regression analyses were performed to compare the survival of patients with different smoking history. Interactions between ATE and (A) tumor subsite and (B) excessive alcohol consumption (EAC) on the survival were evaluated using multivariable Cox regression analyses with interaction terms.

RESULTS: We included 1717 patients with known smoking status (62.8% males, median age: 64 years (IQR: 57-71 years)), who had a 5-year OS of 53.7% (95%CI: 49.8%-57.9%). Based on fully adjusted multivariable Cox regression analyses, significantly elevated hazard ratios (HRs) for OS and DFS were identified for current, but not former smokers, compared to never-smokers. An approximately linear relationship between continuous ATE and survival estimates was identified. ATE analyzed as a categorical variable showed significantly elevated HRs for OS of patients with all categories (0<x ≤ 30, 30<x ≤ 60, and >60 PYs), however only for DFS of patients with >60 PYs, compared to 0 PYs. Furthermore, an unfavorable long-term prognosis was evident after >3.5 (OS) and >2.5 (DFS) years from diagnosis for patients who continued smoking compared to patients with smoking cessation at diagnosis. The survival estimates of patients with different tumor subsite and alcohol consumption differed with increasing ATE.

CONCLUSION: Tobacco smoking (assessed as smoking status and ATE) was associated with inferior survival (OS and DFS) among patients with OSCC. Unfavorable long-term prognosis was significant for patients who continued smoking compared to patients with smoking cessation at diagnosis. The impact of ATE on survival of patients with OSCC may depend on the tumor subsite and/or alcohol consumption.

TidsskriftActa Oncologica
Udgave nummer4
Sider (fra-til)449-458
Antal sider10
StatusUdgivet - apr. 2022

ID: 76236805