Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The impact of rifaximin on inflammation and metabolism in alcoholic hepatitis: A randomized clinical trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Pyridoxine or pyridoxal-5-phosphate treatment for seizures in glycosylphosphatidylinositol deficiency: A cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Behandling af navlebrok hos patienter med cirrose

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Determination of hepatic clearance by derivations of the indocyanine green retention test in cirrhosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. No effect of triheptanoin in patients with phosphofructokinase deficiency

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND AND AIMS: Alcoholic hepatitis (AH) is characterized by acute liver failure, neurocognitive impairment and renal failure. Severe inflammatory reactions are also known to occur in AH. Inflammation and bacterial translocation in the gut are thought to have major impact on disease development and progression. The mortality rate for AH is close to 50%. We aimed to assess the efficacy of rifaximin in treating AH and its impact on inflammation and metabolism.

METHODS: The trial was approved by relevant authorities (EudraCT no: 2014-02264-33, Scientific Ethics Committee, jr. no: H-1-2014-056). Primary outcomes were changes in metabolic and inflammatory markers. Secondary outcomes were portal hypertension, kidney and neurocognitive function.

RESULTS: Thirty-two patients were randomized to standard medical therapy (SMT) or SMT plus rifaximin, allocation was concealed. Four patients in the SMT group and five patients in the SMT + rifaximin group died due to AH and liver failure. No adverse events related to the study medication were observed. We found no significant differences in amino acids or inflammation markers (IL-2, IL-6, IL-8, IL-10, TNF-α, interferon-γ) between the groups after 28 and 90 days.

CONCLUSION: Rifaximin does not alter inflammation or metabolism in patients with AH.

OriginalsprogEngelsk
Artikelnummere0264278
TidsskriftPLoS One
Vol/bind17
Udgave nummer3
Sider (fra-til)1-13
Antal sider13
ISSN1932-6203
DOI
StatusUdgivet - 14 mar. 2022

ID: 75599532