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The impact of loading, unloading, ageing and injury on the human tendon

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@article{2fa3bcb8356f4bc897ff78c8c8348fee,
title = "The impact of loading, unloading, ageing and injury on the human tendon",
abstract = "A tendon transfers force from the contracting muscle to the skeletal system to produce movement and is therefore a crucial component of the entire muscle-tendon complex and its function. However, tendon research has for some time focused on mechanical properties without any major appreciation of potential cellular and molecular changes. At the same time, methodological developments have permitted determination of the mechanical properties of human tendons in vivo, which was previously not possible. Here we review the current understanding of how tendons respond to loading, unloading, ageing and injury from cellular, molecular and mechanical points of view. A mechanistic understanding of tendon tissue adaptation will be vital for development of adequate guidelines in physical training and rehabilitation, as well as for optimal injury treatment.",
author = "Magnusson, {S Peter} and Michael Kjaer",
note = "{\textcopyright} 2018 The Authors. The Journal of Physiology {\textcopyright} 2018 The Physiological Society.",
year = "2019",
month = jun,
day = "19",
doi = "10.1113/JP275450",
language = "English",
journal = "The Journal of physiology",
issn = "0022-3751",
publisher = "Wiley-Blackwell Publishing Ltd",

}

RIS

TY - JOUR

T1 - The impact of loading, unloading, ageing and injury on the human tendon

AU - Magnusson, S Peter

AU - Kjaer, Michael

N1 - © 2018 The Authors. The Journal of Physiology © 2018 The Physiological Society.

PY - 2019/6/19

Y1 - 2019/6/19

N2 - A tendon transfers force from the contracting muscle to the skeletal system to produce movement and is therefore a crucial component of the entire muscle-tendon complex and its function. However, tendon research has for some time focused on mechanical properties without any major appreciation of potential cellular and molecular changes. At the same time, methodological developments have permitted determination of the mechanical properties of human tendons in vivo, which was previously not possible. Here we review the current understanding of how tendons respond to loading, unloading, ageing and injury from cellular, molecular and mechanical points of view. A mechanistic understanding of tendon tissue adaptation will be vital for development of adequate guidelines in physical training and rehabilitation, as well as for optimal injury treatment.

AB - A tendon transfers force from the contracting muscle to the skeletal system to produce movement and is therefore a crucial component of the entire muscle-tendon complex and its function. However, tendon research has for some time focused on mechanical properties without any major appreciation of potential cellular and molecular changes. At the same time, methodological developments have permitted determination of the mechanical properties of human tendons in vivo, which was previously not possible. Here we review the current understanding of how tendons respond to loading, unloading, ageing and injury from cellular, molecular and mechanical points of view. A mechanistic understanding of tendon tissue adaptation will be vital for development of adequate guidelines in physical training and rehabilitation, as well as for optimal injury treatment.

U2 - 10.1113/JP275450

DO - 10.1113/JP275450

M3 - Journal article

C2 - 29920664

JO - The Journal of physiology

JF - The Journal of physiology

SN - 0022-3751

ER -

ID: 56199178