TY - JOUR
T1 - The impact of hypoglycaemia on quality of life among adults with type 1 diabetes
T2 - Results from "YourSAY: Hypoglycaemia"
AU - Chatwin, Hannah
AU - Broadley, Melanie
AU - Hendrieckx, Christel
AU - Carlton, Jill
AU - Heller, Simon
AU - Amiel, Stephanie A
AU - de Galan, Bastiaan
AU - McCrimmon, Rory J
AU - Pedersen-Bjergaard, Ulrik
AU - Pouwer, Frans
AU - Speight, Jane
AU - Hypo-RESOLVE consortium
N1 - Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2023/11
Y1 - 2023/11
N2 - AIMS: Research on hypoglycaemia and quality of life (QoL) has focused mostly on severe hypoglycaemia and psychological outcomes, with less known about other aspects of hypoglycaemia (e.g., self-treated episodes) and impacts on other QoL domains (e.g., relationships). Therefore, we examined the impact of all aspects of hypoglycaemia on QoL in adults with type 1 diabetes (T1DM).METHODS: Participants completed an online survey, including assessment of hypoglycaemia-specific QoL (using the 12-item Hypoglycaemia Impact Profile). Mann-Whitney U tests examined differences in hypoglycaemia-specific QoL by hypoglycaemia frequency, severity, and awareness. Hierarchical linear regression examined associations with QoL.RESULTS: Participants were 1028 adults with T1DM (M ± SD age: 47 ± 15 years; diabetes duration: 27 ± 16 years). Severe and self-treated hypoglycaemia and impaired awareness negatively impacted on overall QoL and several QoL domains, including leisure activities, physical health, ability to keep fit/be active, sleep, emotional well-being, spontaneity, independence, work/studies, and dietary freedom. Diabetes distress was most strongly associated with hypoglycaemia-specific QoL, followed by generic emotional well-being, fear of hypoglycaemia, and confidence in managing hypoglycaemia. Hypoglycaemia frequency and awareness were no longer significantly associated with QoL once psychological factors were considered.CONCLUSIONS: Hypoglycaemia negatively impacts on several QoL domains. Psychological factors supersede the effect of hypoglycaemia frequency and awareness in accounting for this negative impact.
AB - AIMS: Research on hypoglycaemia and quality of life (QoL) has focused mostly on severe hypoglycaemia and psychological outcomes, with less known about other aspects of hypoglycaemia (e.g., self-treated episodes) and impacts on other QoL domains (e.g., relationships). Therefore, we examined the impact of all aspects of hypoglycaemia on QoL in adults with type 1 diabetes (T1DM).METHODS: Participants completed an online survey, including assessment of hypoglycaemia-specific QoL (using the 12-item Hypoglycaemia Impact Profile). Mann-Whitney U tests examined differences in hypoglycaemia-specific QoL by hypoglycaemia frequency, severity, and awareness. Hierarchical linear regression examined associations with QoL.RESULTS: Participants were 1028 adults with T1DM (M ± SD age: 47 ± 15 years; diabetes duration: 27 ± 16 years). Severe and self-treated hypoglycaemia and impaired awareness negatively impacted on overall QoL and several QoL domains, including leisure activities, physical health, ability to keep fit/be active, sleep, emotional well-being, spontaneity, independence, work/studies, and dietary freedom. Diabetes distress was most strongly associated with hypoglycaemia-specific QoL, followed by generic emotional well-being, fear of hypoglycaemia, and confidence in managing hypoglycaemia. Hypoglycaemia frequency and awareness were no longer significantly associated with QoL once psychological factors were considered.CONCLUSIONS: Hypoglycaemia negatively impacts on several QoL domains. Psychological factors supersede the effect of hypoglycaemia frequency and awareness in accounting for this negative impact.
KW - Adult
KW - Diabetes Mellitus, Type 1/complications
KW - Fear/psychology
KW - Humans
KW - Hypoglycemia/psychology
KW - Hypoglycemic Agents
KW - Middle Aged
KW - Quality of Life
UR - http://www.scopus.com/inward/record.url?scp=85135368943&partnerID=8YFLogxK
U2 - 10.1016/j.jdiacomp.2022.108232
DO - 10.1016/j.jdiacomp.2022.108232
M3 - Journal article
C2 - 35927177
SN - 1056-8727
VL - 37
SP - 108232
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
IS - 11
M1 - 108232
ER -