The impact of center experience on results of reduced intensity:allogeneic hematopoietic SCT for AML. An analysis from the Acute Leukemia Working Party of the EBMT

S Giebel; M Labopin; M Mohty; G J Mufti; D Niederwieser; Joep Cornelissen; J J W M Janssen; N Milpied; L Vindelov; E Petersen; R Arnold; A Bacigalupo; D Blaise; C Craddock; A Nagler; F Frassoni; M Sadus-Wojciechowska; V Rocha

doi:10.1038/bmt.2012.131

The impact of center experience on results of reduced intensity:allogeneic hematopoietic SCT for AML. An analysis from the Acute Leukemia Working Party of the EBMT

S Giebel, M Labopin, M Mohty, G J Mufti, D Niederwieser, Joep Cornelissen, J J W M Janssen, N Milpied, L Vindelov, E Petersen, R Arnold, A Bacigalupo, D Blaise, C Craddock, A Nagler, F Frassoni, M Sadus-Wojciechowska, V Rocha

26 Citationer (Scopus)

Abstract

Allogeneic hematopoietic SCT with reduced-intensity conditioning (RIC-HSCT) is increasingly adopted for the treatment of older adults with AML. Our goal was to verify for the first time, if center experience influences outcome of RIC-HSCT. Results of 1413 transplantations from HLA-matched related or unrelated donors for adult patients with AML in first CR were analyzed according to the level of center activity. Transplants were performed in 203 European centers between 2001 and 2007. The 2-year probability of leukemia-free survival (LFS) after RIC-HSCT performed in centers with the lowest activity (15 procedures/7 years) was 43±3% compared with 55±2% in the remainder (P

Originalsprog	Engelsk
Tidsskrift	Bone Marrow Transplantation
Vol/bind	48
Udgave nummer	2
Sider (fra-til)	238-42
ISSN	0268-3369
DOI	https://doi.org/10.1038/bmt.2012.131
Status	Udgivet - 2013

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10.1038/bmt.2012.131

Citationsformater

Giebel, S., Labopin, M., Mohty, M., Mufti, G. J., Niederwieser, D., Cornelissen, J., Janssen, J. J. W. M., Milpied, N., Vindelov, L., Petersen, E., Arnold, R., Bacigalupo, A., Blaise, D., Craddock, C., Nagler, A., Frassoni, F., Sadus-Wojciechowska, M., & Rocha, V. (2013). The impact of center experience on results of reduced intensity:allogeneic hematopoietic SCT for AML. An analysis from the Acute Leukemia Working Party of the EBMT. Bone Marrow Transplantation, 48(2), 238-42. https://doi.org/10.1038/bmt.2012.131

Giebel, S, Labopin, M, Mohty, M, Mufti, GJ, Niederwieser, D, Cornelissen, J, Janssen, JJWM, Milpied, N, Vindelov, L, Petersen, E, Arnold, R, Bacigalupo, A, Blaise, D, Craddock, C, Nagler, A, Frassoni, F, Sadus-Wojciechowska, M & Rocha, V 2013, 'The impact of center experience on results of reduced intensity:allogeneic hematopoietic SCT for AML. An analysis from the Acute Leukemia Working Party of the EBMT', Bone Marrow Transplantation, bind 48, nr. 2, s. 238-42. https://doi.org/10.1038/bmt.2012.131

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title = "The impact of center experience on results of reduced intensity:allogeneic hematopoietic SCT for AML. An analysis from the Acute Leukemia Working Party of the EBMT",

abstract = "Allogeneic hematopoietic SCT with reduced-intensity conditioning (RIC-HSCT) is increasingly adopted for the treatment of older adults with AML. Our goal was to verify for the first time, if center experience influences outcome of RIC-HSCT. Results of 1413 transplantations from HLA-matched related or unrelated donors for adult patients with AML in first CR were analyzed according to the level of center activity. Transplants were performed in 203 European centers between 2001 and 2007. The 2-year probability of leukemia-free survival (LFS) after RIC-HSCT performed in centers with the lowest activity (15 procedures/7 years) was 43±3% compared with 55±2% in the remainder (P",

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year = "2013",

doi = "10.1038/bmt.2012.131",

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AU - Giebel, S

AU - Labopin, M

AU - Mohty, M

AU - Mufti, G J

AU - Niederwieser, D

AU - Cornelissen, Joep

AU - Janssen, J J W M

AU - Milpied, N

AU - Vindelov, L

AU - Petersen, E

AU - Arnold, R

AU - Bacigalupo, A

AU - Blaise, D

AU - Craddock, C

AU - Nagler, A

AU - Frassoni, F

AU - Sadus-Wojciechowska, M

AU - Rocha, V

PY - 2013

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N2 - Allogeneic hematopoietic SCT with reduced-intensity conditioning (RIC-HSCT) is increasingly adopted for the treatment of older adults with AML. Our goal was to verify for the first time, if center experience influences outcome of RIC-HSCT. Results of 1413 transplantations from HLA-matched related or unrelated donors for adult patients with AML in first CR were analyzed according to the level of center activity. Transplants were performed in 203 European centers between 2001 and 2007. The 2-year probability of leukemia-free survival (LFS) after RIC-HSCT performed in centers with the lowest activity (15 procedures/7 years) was 43±3% compared with 55±2% in the remainder (P

AB - Allogeneic hematopoietic SCT with reduced-intensity conditioning (RIC-HSCT) is increasingly adopted for the treatment of older adults with AML. Our goal was to verify for the first time, if center experience influences outcome of RIC-HSCT. Results of 1413 transplantations from HLA-matched related or unrelated donors for adult patients with AML in first CR were analyzed according to the level of center activity. Transplants were performed in 203 European centers between 2001 and 2007. The 2-year probability of leukemia-free survival (LFS) after RIC-HSCT performed in centers with the lowest activity (15 procedures/7 years) was 43±3% compared with 55±2% in the remainder (P

U2 - 10.1038/bmt.2012.131

DO - 10.1038/bmt.2012.131

M3 - Journal article

C2 - 22773125

SN - 0268-3369

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JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

IS - 2

ER -

The impact of center experience on results of reduced intensity:allogeneic hematopoietic SCT for AML. An analysis from the Acute Leukemia Working Party of the EBMT

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