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The impact of axon orientation dispersion and 3D diameter variations on the transverse apparent diffusion coefficient

Publikation: Bidrag til bog/antologi/rapportKonferenceabstrakt i proceedingsForskningpeer review

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Vis graf over relationer
We extract the orientation dispersion (OD) and 3D axon diameter variations of long axons (>100 µm) from an ultra-high resolution, synchrotron X-ray nano-holotomography (XNH) scan of the monkey splenium. From this, we discover a relationship between mean axon diameter and along-axon diameter variations. Monte Carlo simulations are then performed on the intra-axonal spaces (IAS) of different substrates which inherit their morphological features from the segmented axons. These simulations show that the OD significantly affects the transverse apparent diffusion coefficient (ADC⟂) of the axon substrate at diffusion times up to 50 ms, while diameter variations do not.
OriginalsprogEngelsk
TitelProceedings of the 2020 ISMRM & SMRT Virtual Conference & Exhibition
Antal sider3
ForlagThe International Society for Magnetic Resonance in Medicine
Publikationsdatoaug. 2020
Sider1-3
Artikelnummer0712
StatusUdgivet - aug. 2020
BegivenhedISMRM & SMRT Virtual Conference & Exhibition 2020 - Virtual conference
Varighed: 8 aug. 202014 aug. 2020
https://www.ismrm.org/20m/

Konference

KonferenceISMRM & SMRT Virtual Conference & Exhibition 2020
LokationVirtual conference
Periode08/08/202014/08/2020
Internetadresse

Begivenhed

ISMRM & SMRT Virtual Conference & Exhibition 2020

08/08/202014/08/2020

Begivenhed: Konference

ID: 62005591