Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The impact of a stewardship program on antibiotic administration in community-acquired pneumonia: results from an observational before-after study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Recent increased incidence of invasive serogroup W meningococcal disease: A retrospective observational study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Oral and anal carriage of Neisseria meningitidis among sexually active HIV-infected men who have sex with men in Denmark 2014-15

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Silent Hypoxia in Patients with SARS CoV-2 Infection before Hospital Discharge

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Hepatic steatosis associated with exposure to elvitegravir and raltegravir

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Recent increased incidence of invasive serogroup W meningococcal disease: A retrospective observational study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. A case of thrombocytopenia and multiple thromboses after vaccination with ChAdOx1 nCoV-19 against SARS-CoV-2

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The Association of Low Vitamin K Status with Mortality in a Cohort of 138 Hospitalized Patients with COVID-19

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: A majority of patients with community-acquired pneumonia (CAP) receive antibiotics. According to the evidence, 5-7 days of treatment should be sufficient for most patients. Many, however, are treated longer than recommended. We have previously conducted a quality improvement study to ensure guideline-conform treatment for CAP. However, the impact of the interventions on antibiotic use has not been investigated.

OBJECTIVE: To estimate the impact of an eight-month stewardship program on antibiotic use.

METHODS: We conducted a before-after study comparing a four-month baseline period with data from a corresponding follow-up period. We performed univariable and multivariable logistic regression to compare odds for ≤7 days of total antibiotic treatment, ≤3 days of intravenous treatment and the proportion of correct empiric antibiotics. As sensitivity analysis, we repeated the univariable logistic regression on a propensity score-matched cohort by using the same variables we used for adjustments in the multivariable analysis. We also performed subgroup analyses for patients stable ≤72 h of admission.

RESULTS: In total, 771 patients were included. Compared to preintervention, the unadjusted odds ratio (OR) for ≤7 days of total antibiotic treatment were 1.84 (95% CI 1.34-2.54) for the whole population and 2.08 (1.41-3.10) for the stable patients. The OR for ≤3 days of intravenous antibiotics were 1.16 (0.87-1.54) and 1.38 (0.87-2.22), respectively. The OR for correct empiric antibiotics were 1.96 (1.45-2.68) and 1.82 (1.23-2.69). Comparable results regarding all outcomes were derived from the other analyses.

CONCLUSION: The programme resulted in a significantly lower overall antibiotic exposure and a higher proportion of patients treated with the recommended antibiotics without a the reduction of exposure to intravenous antibiotics significantly.

OriginalsprogEngelsk
TidsskriftInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Vol/bind103
Sider (fra-til)208-213
Antal sider6
ISSN1201-9712
DOI
StatusUdgivet - 1 feb. 2021

ID: 61340611