The hepatic glutathione content in liver diseases

H E Poulsen, L Ranek, P B Andreasen

Abstract

We measured the total glutathione content in 38 liver biopsies from patients undergoing diagnostic liver biopsy to study whether liver diseases result in decreased glutathione content making the liver more sensitive to different toxic damages. The glutathione concentrations ranged from 20.2 to 41.0 mumol/g hepatic protein in six biopsies without light microscopic pathological changes (mean +/- SD = 26.9 = +/- 8.1). The mean concentrations +/- SD in patients with toxic hepatitis (n = 3), viral hepatitis (n = 4), chronic active hepatitis (n = 4), cirrhosis (n = 14) and steatosis (n = 7) were 62.5 +/- 27.2, 47.4 +/- 25.9, 38.3 +/- 17.0, 29.1 +/- 15.7 and 21.0 +/- 9.6, respectively. The hepatic glutathione content is not decreased in patients with moderate hepatic impairment.

OriginalsprogEngelsk
TidsskriftScandinavian Journal of Clinical and Laboratory Investigation
Vol/bind41
Udgave nummer6
Sider (fra-til)573-6
Antal sider4
ISSN0036-5513
DOI
StatusUdgivet - okt. 1981

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