The fifth cranial nerve in headaches

J C A Edvinsson; A Viganò; A Alekseeva; E Alieva; R Arruda; C De Luca; N D'Ettore; I Frattale; M Kurnukhina; N Macerola; E Malenkova; M Maiorova; A Novikova; P Řehulka; V Rapaccini; O Roshchina; G Vanderschueren; L Zvaune; A P Andreou; K A Haanes; European Headache Federation School of Advanced Studies (EHF-SAS)

doi:10.1186/s10194-020-01134-1

The fifth cranial nerve in headaches

J C A Edvinsson, A Viganò, A Alekseeva, E Alieva, R Arruda, C De Luca, N D'Ettore, I Frattale, M Kurnukhina, N Macerola, E Malenkova, M Maiorova, A Novikova, P Řehulka, V Rapaccini, O Roshchina, G Vanderschueren, L Zvaune, A P Andreou, K A HaanesEuropean Headache Federation School of Advanced Studies (EHF-SAS)

Klinisk Eksperimentel Forskningsafdeling Rigshospitalet

123 Citationer (Scopus)

Abstract

The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists.

Originalsprog	Engelsk
Tidsskrift	The Journal of Headache and Pain Online
Vol/bind	21
Udgave nummer	1
Sider (fra-til)	65
ISSN	1129-2377
DOI	https://doi.org/10.1186/s10194-020-01134-1
Status	Udgivet - 2020

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10.1186/s10194-020-01134-1

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Edvinsson, J. C. A., Viganò, A., Alekseeva, A., Alieva, E., Arruda, R., De Luca, C., D'Ettore, N., Frattale, I., Kurnukhina, M., Macerola, N., Malenkova, E., Maiorova, M., Novikova, A., Řehulka, P., Rapaccini, V., Roshchina, O., Vanderschueren, G., Zvaune, L., Andreou, A. P., ... European Headache Federation School of Advanced Studies (EHF-SAS) (2020). The fifth cranial nerve in headaches. The Journal of Headache and Pain Online, 21(1), 65. https://doi.org/10.1186/s10194-020-01134-1

Edvinsson, JCA, Viganò, A, Alekseeva, A, Alieva, E, Arruda, R, De Luca, C, D'Ettore, N, Frattale, I, Kurnukhina, M, Macerola, N, Malenkova, E, Maiorova, M, Novikova, A, Řehulka, P, Rapaccini, V, Roshchina, O, Vanderschueren, G, Zvaune, L, Andreou, AP, Haanes, KA & European Headache Federation School of Advanced Studies (EHF-SAS) 2020, 'The fifth cranial nerve in headaches', The Journal of Headache and Pain Online, bind 21, nr. 1, s. 65. https://doi.org/10.1186/s10194-020-01134-1

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abstract = "The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists.",

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AU - De Luca, C

AU - D'Ettore, N

AU - Frattale, I

AU - Kurnukhina, M

AU - Macerola, N

AU - Malenkova, E

AU - Maiorova, M

AU - Novikova, A

AU - Řehulka, P

AU - Rapaccini, V

AU - Roshchina, O

AU - Vanderschueren, G

AU - Zvaune, L

AU - Andreou, A P

AU - Haanes, K A

AU - European Headache Federation School of Advanced Studies (EHF-SAS)

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AB - The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists.

KW - CGRP

KW - Fifth cranial nerve

KW - Headache

KW - Migraine pathophysiology

KW - Treatments

KW - Trigeminal ganglion

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The fifth cranial nerve in headaches

Abstract

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