The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions

Fysik og astronomi

• pseudomonas 100%
• peptides 76%
• mutations 34%
• cystic fibrosis 17%
• phenotype 13%
• sequencing 13%
• genome 12%
• regulators 12%
• infectious diseases 12%
• loci 11%
• high resistance 11%
• predictions 5%

Medicin og biovidenskab

• Colistin 88%
• Pseudomonas aeruginosa 64%
• Peptides 44%
• Mutation 29%
• Gram-Negative Bacterial Infections 26%
• Whole Genome Sequencing 20%
• Cystic Fibrosis 16%
• Phenotype 10%
• In Vitro Techniques 7%
• Therapeutics 2%

Kemi

• Polypeptide Antibiotic Agent 76%
• Resistance 43%
• Colistin 42%
• Mutation 22%