Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The evidence of neuraxial administration of analgesics for cancer-related pain: a systematic review

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Anesthesiologists’ airway management expertise: Identifying subjective and objective knowledge gaps

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Characteristics, interventions and longer-term outcomes of COVID-19 ICU patients in Denmark - a nationwide, observational study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Risk factors for long-term cognitive impairment in ICU survivors: A multicenter, prospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Methylphenidate as Needed for Fatigue in Patients With Advanced Cancer. A Prospective, Double-Blind, and Placebo-Controlled Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Validation of a Battery of Neuropsychological Tests for Patients With Metastatic Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Oncology to specialised palliative home care systematic transition: the Domus randomised trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: The present systematic review analysed the existing evidence of analgesic efficacy and side effects of opioids without and with adjuvant analgesics delivered by neuraxial route (epidural and subarachnoid) in adult patients with cancer.

METHODS: Search strategy was elaborated with words related to cancer, pain, neuraxial route, analgesic and side effects. The search was performed in PubMed, EMBASE, and Cochrane for the period until February 2014. Studies were analysed according to methods, results, quality of evidence, and strength of recommendation.

RESULTS: The number of abstracts retrieved was 2147, and 84 articles were selected for full reading. The final selection comprised nine articles regarding randomised controlled trials (RCTs) divided in four groups: neuraxial combinations of opioid and adjuvant analgesic compared with neuraxial administration of opioid alone (n = 4); single neuraxial drug in bolus compared with continuous administration (n = 2); single neuraxial drug compared with neuraxial placebo (n = 1); and neuraxial opioid combined with or without adjuvant analgesic compared with other comprehensive medical management than neuraxial analgesics (n = 2). The RCTs presented clinical and methodological diversity that precluded a meta-analysis. They also presented several limitations, which reduced study internal validity. However, they demonstrated better pain control for all interventions analysed. Side effects were described, but there were few significant differences in favour of the tested interventions.

CONCLUSION: Heterogeneous characteristics and several methodological limitations of the studies resulted in evidence of low quality and a weak recommendation for neuraxial administration of opioids with or without adjuvant analgesics in adult patients with cancer.

OriginalsprogEngelsk
TidsskriftActa Anaesthesiologica Scandinavica
Vol/bind59
Udgave nummer9
Sider (fra-til)1103-15
Antal sider13
ISSN0001-5172
DOI
StatusUdgivet - okt. 2015

ID: 46057567