The evidence for antiresorptive osteoporosis treatment in the elderly and old

Purpose. – The mean age at diagnosis of osteoporosis is in the late 1960s, and fracture risk and need for
fracture prevention rises sharply with increasing age. However, what is the evidence that supports the
use of antiresorptive osteoporosis treatments in elderly people?
Methods. – This study was a meta-analysis and meta-regression of the published literature on the
clinical efficacy of antiresorptive therapy in the reduction of fracture risk in elderly (age > 70 years) and
old (age > 80 years). A systematic literature search was performed. Studies included were randomised
placebo controlled trials of post-menopausal women or men where the primary endpoint was vertebral,
non-vertebral or hip fracture risk reduction. No papers on fractures in males were published, so BMD as
primary endpoint was accepted.
Results. – Thirteen studies in women were included. We found increasing vertebral fracture risk
reduction with increasing age, increasing BMI, and longer duration of treatment. A high baseline BMD
was associated with a lesser effect. For non-vertebral fracture risk reduction, we found no effect of
follow-up, age or BMD. For hip fracture risk reduction, we found no effect of treatment with increasing
age or BMD, and no certain effect of duration of treatment. For men, three BMD studies were included, in
these, we found a non-significant trend toward fracture reduction.
Conclusions. – For women, pooled analyses showed increasing effect of antiresorptive drugs with
increasing age, increasing BMI, and longer duration of treatment on vertebral fractures. The data on nonvertebral or hip fractures showed no effect on follow-up, age, or BMD. The data in men are scant at all
sites and inconclusive.