The epidemic of methylisothiazolinone: a European prospective study

Jakob Ferløv Schwensen; Wolfgang Uter; Magnus Bruze; Cecilia Svedman; An Goossens; Mark Wilkinson; Ana Gimenez-Arnau; Margarida Gonçalo; Klaus E Andersen; Evy Paulsen; Tove Agner; Caterina Foti; Kristiina Aalto-Korte; John McFadden; Ian White; Jeanne D Johansen; European Environmental Contact Dermatitis Research Group

doi:10.1111/cod.12733

The epidemic of methylisothiazolinone: a European prospective study

Jakob Ferløv Schwensen, Wolfgang Uter, Magnus Bruze, Cecilia Svedman, An Goossens, Mark Wilkinson, Ana Gimenez-Arnau, Margarida Gonçalo, Klaus E Andersen, Evy Paulsen, Tove Agner, Caterina Foti, Kristiina Aalto-Korte, John McFadden, Ian White, Jeanne D Johansen, European Environmental Contact Dermatitis Research Group

75 Citationer (Scopus)

Abstract

BACKGROUND: The use of methylisothiazolinone (MI) in cosmetic products has caused an unprecedented epidemic of MI contact allergy. Current data concerning exposures at a European level are required.

OBJECTIVES: To describe demographics and MI exposures for European patients with MI contact allergy.

METHODS: Eleven European dermatology departments from eight European countries prospectively collected data between 1 May and 31 October 2015 among consecutive patients who had positive patch test reactions to MI (2000 ppm aq.).

RESULTS: A total of 6.0% (205/3434; range 2.6-13.0%) of patients had positive patch test reactions to MI. Dermatitis most frequently affected the hands (43.4%), face (32.7%), arms (14.6%), and eyelids (11.7%); 12.7% had widespread dermatitis. For 72.7% (149/205), MI contact allergy was currently relevant mainly because of exposure to cosmetic products (83.2%; 124/149). Of these 124 patients, 19.5% were exposed to leave-on and rinse-off cosmetic products, 24.8% only to leave-on cosmetic products and 38.9% only to rinse-off cosmetic products containing MI or methylchloroisothiazolinone/MI. The majority of these (79%) noted onset of their dermatitis between 2013 and 2015. Fifteen patients (7.3%) had previously experienced allergic reactions when they were in newly painted rooms.

CONCLUSION: Clinically relevant MI contact allergy remains prevalent across European countries, mainly because of exposure to rinse-off and leave-on cosmetic products.

Originalsprog	Engelsk
Tidsskrift	Contact Dermatitis
Vol/bind	76
Udgave nummer	5
Sider (fra-til)	272-279
Antal sider	8
ISSN	0105-1873
DOI	https://doi.org/10.1111/cod.12733
Status	Udgivet - maj 2017

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10.1111/cod.12733

Citationsformater

Ferløv Schwensen, J., Uter, W., Bruze, M., Svedman, C., Goossens, A., Wilkinson, M., Gimenez-Arnau, A., Gonçalo, M., Andersen, K. E., Paulsen, E., Agner, T., Foti, C., Aalto-Korte, K., McFadden, J., White, I., Johansen, J. D., & European Environmental Contact Dermatitis Research Group (2017). The epidemic of methylisothiazolinone: a European prospective study. Contact Dermatitis, 76(5), 272-279. https://doi.org/10.1111/cod.12733

Ferløv Schwensen, J, Uter, W, Bruze, M, Svedman, C, Goossens, A, Wilkinson, M, Gimenez-Arnau, A, Gonçalo, M, Andersen, KE, Paulsen, E, Agner, T, Foti, C, Aalto-Korte, K, McFadden, J, White, I, Johansen, JD & European Environmental Contact Dermatitis Research Group 2017, 'The epidemic of methylisothiazolinone: a European prospective study', Contact Dermatitis, bind 76, nr. 5, s. 272-279. https://doi.org/10.1111/cod.12733

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title = "The epidemic of methylisothiazolinone: a European prospective study",

abstract = "BACKGROUND: The use of methylisothiazolinone (MI) in cosmetic products has caused an unprecedented epidemic of MI contact allergy. Current data concerning exposures at a European level are required.OBJECTIVES: To describe demographics and MI exposures for European patients with MI contact allergy.METHODS: Eleven European dermatology departments from eight European countries prospectively collected data between 1 May and 31 October 2015 among consecutive patients who had positive patch test reactions to MI (2000 ppm aq.).RESULTS: A total of 6.0% (205/3434; range 2.6-13.0%) of patients had positive patch test reactions to MI. Dermatitis most frequently affected the hands (43.4%), face (32.7%), arms (14.6%), and eyelids (11.7%); 12.7% had widespread dermatitis. For 72.7% (149/205), MI contact allergy was currently relevant mainly because of exposure to cosmetic products (83.2%; 124/149). Of these 124 patients, 19.5% were exposed to leave-on and rinse-off cosmetic products, 24.8% only to leave-on cosmetic products and 38.9% only to rinse-off cosmetic products containing MI or methylchloroisothiazolinone/MI. The majority of these (79%) noted onset of their dermatitis between 2013 and 2015. Fifteen patients (7.3%) had previously experienced allergic reactions when they were in newly painted rooms.CONCLUSION: Clinically relevant MI contact allergy remains prevalent across European countries, mainly because of exposure to rinse-off and leave-on cosmetic products.",

keywords = "Journal Article",

author = "{Ferl{\o}v Schwensen}, Jakob and Wolfgang Uter and Magnus Bruze and Cecilia Svedman and An Goossens and Mark Wilkinson and Ana Gimenez-Arnau and Margarida Gon{\c c}alo and Andersen, {Klaus E} and Evy Paulsen and Tove Agner and Caterina Foti and Kristiina Aalto-Korte and John McFadden and Ian White and Johansen, {Jeanne D} and {European Environmental Contact Dermatitis Research Group}",

note = "{\textcopyright} 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.",

year = "2017",

month = may,

doi = "10.1111/cod.12733",

language = "English",

volume = "76",

pages = "272--279",

journal = "Contact Dermatitis",

issn = "0105-1873",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - The epidemic of methylisothiazolinone

T2 - a European prospective study

AU - Ferløv Schwensen, Jakob

AU - Uter, Wolfgang

AU - Bruze, Magnus

AU - Svedman, Cecilia

AU - Goossens, An

AU - Wilkinson, Mark

AU - Gimenez-Arnau, Ana

AU - Gonçalo, Margarida

AU - Andersen, Klaus E

AU - Paulsen, Evy

AU - Agner, Tove

AU - Foti, Caterina

AU - Aalto-Korte, Kristiina

AU - McFadden, John

AU - White, Ian

AU - Johansen, Jeanne D

AU - European Environmental Contact Dermatitis Research Group

PY - 2017/5

Y1 - 2017/5

N2 - BACKGROUND: The use of methylisothiazolinone (MI) in cosmetic products has caused an unprecedented epidemic of MI contact allergy. Current data concerning exposures at a European level are required.OBJECTIVES: To describe demographics and MI exposures for European patients with MI contact allergy.METHODS: Eleven European dermatology departments from eight European countries prospectively collected data between 1 May and 31 October 2015 among consecutive patients who had positive patch test reactions to MI (2000 ppm aq.).RESULTS: A total of 6.0% (205/3434; range 2.6-13.0%) of patients had positive patch test reactions to MI. Dermatitis most frequently affected the hands (43.4%), face (32.7%), arms (14.6%), and eyelids (11.7%); 12.7% had widespread dermatitis. For 72.7% (149/205), MI contact allergy was currently relevant mainly because of exposure to cosmetic products (83.2%; 124/149). Of these 124 patients, 19.5% were exposed to leave-on and rinse-off cosmetic products, 24.8% only to leave-on cosmetic products and 38.9% only to rinse-off cosmetic products containing MI or methylchloroisothiazolinone/MI. The majority of these (79%) noted onset of their dermatitis between 2013 and 2015. Fifteen patients (7.3%) had previously experienced allergic reactions when they were in newly painted rooms.CONCLUSION: Clinically relevant MI contact allergy remains prevalent across European countries, mainly because of exposure to rinse-off and leave-on cosmetic products.

AB - BACKGROUND: The use of methylisothiazolinone (MI) in cosmetic products has caused an unprecedented epidemic of MI contact allergy. Current data concerning exposures at a European level are required.OBJECTIVES: To describe demographics and MI exposures for European patients with MI contact allergy.METHODS: Eleven European dermatology departments from eight European countries prospectively collected data between 1 May and 31 October 2015 among consecutive patients who had positive patch test reactions to MI (2000 ppm aq.).RESULTS: A total of 6.0% (205/3434; range 2.6-13.0%) of patients had positive patch test reactions to MI. Dermatitis most frequently affected the hands (43.4%), face (32.7%), arms (14.6%), and eyelids (11.7%); 12.7% had widespread dermatitis. For 72.7% (149/205), MI contact allergy was currently relevant mainly because of exposure to cosmetic products (83.2%; 124/149). Of these 124 patients, 19.5% were exposed to leave-on and rinse-off cosmetic products, 24.8% only to leave-on cosmetic products and 38.9% only to rinse-off cosmetic products containing MI or methylchloroisothiazolinone/MI. The majority of these (79%) noted onset of their dermatitis between 2013 and 2015. Fifteen patients (7.3%) had previously experienced allergic reactions when they were in newly painted rooms.CONCLUSION: Clinically relevant MI contact allergy remains prevalent across European countries, mainly because of exposure to rinse-off and leave-on cosmetic products.

KW - Journal Article

U2 - 10.1111/cod.12733

DO - 10.1111/cod.12733

M3 - Journal article

C2 - 28032337

SN - 0105-1873

VL - 76

SP - 272

EP - 279

JO - Contact Dermatitis

JF - Contact Dermatitis

IS - 5

ER -

The epidemic of methylisothiazolinone: a European prospective study

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