Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

The efficacy of topical agents used in wounds for managing chronic biofilm infections: A systematic review

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Incidence, presentation and outcome of toxoplasmosis in HIV infected in the combination antiretroviral therapy era

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Management of MDR-TB in HIV co-infected patients in eastern europe: results from the TB:HIV study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Long-term mortality and causes of death associated with Staphylococcus aureus bacteremia. A matched cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Naturally acquired antibody responses to recombinant Pfs230 and Pfs48/45 transmission blocking vaccine candidates

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The environmental occurrence of Pseudomonas aeruginosa

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Biofilms of Mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Minimum information guideline for spectrofotometric and fluorometric methods to assess biofilm formation in microplates

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Is pseudarthrosis after spinal instrumentation caused by a chronic infection?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • S Schwarzer
  • G A James
  • D Goeres
  • T Bjarnsholt
  • K Vickery
  • S L Percival
  • P Stoodley
  • G Schultz
  • S O Jensen
  • M Malone
Vis graf over relationer

OBJECTIVES: Clinicians have increasingly adopted the widespread use of topical agents to manage chronic wound infections, despite limited data on their effectiveness in vivo. This study sought to evaluate the evidence for commonly employed topical agents used in wounds for the purpose of treating chronic infections caused by biofilm.

METHOD: We included in vitro, animal and human in vivo studies where topical agents were tested for their efficacy against biofilms, for use in wound care. For human studies, we only included those which utilised appropriate identification techniques for visualising and confirming the presence of biofilms.

RESULT: A total of 640 articles were identified, with 43 included after meeting eligibility. In vitro testing accounted for 90% (n = 39) of all included studies, five studies using animal models and three human in vivo studies. Sixteen different laboratory models were utilised, with the most frequent being the minimum biofilm eradication concentration (MBEC™) / well plate assay (38%, n = 15 of 39). A total of 44 commercially available topical agents were grouped into twelve categories with the most commonly tested agents being silver, iodine and polyhexamethylene biguanide (PHMB). In vitro results on efficacy demonstrated iodine as having the highest mean log10 reductions of all agents (4.81, ±3.14).

CONCLUSION: There is large disparity in the translation of laboratory studies to researchers undertaking human trials relating to the effectiveness of commercially available topical agents. There is insufficient human in vivo evidence to definitively recommend any commercially available topical agent over another for the treatment of chronic wound biofilms. The heterogeneity identified between study designs (in vitro to in vivo) further limits the generalisability of results.

OriginalsprogEngelsk
TidsskriftJournal of Infection
Vol/bind80
Udgave nummer3
Sider (fra-til)261-270
Antal sider10
ISSN0163-4453
DOI
StatusUdgivet - mar. 2020

Bibliografisk note

Copyright © 2019. Published by Elsevier Ltd.

ID: 59012082