TY - JOUR
T1 - The Effects of Lifestyle and/or Vitamin D Supplementation Interventions on Pregnancy Outcomes
T2 - What Have We Learned from the DALI Studies?
AU - Harreiter, Jürgen
AU - Desoye, Gernot
AU - van Poppel, Mireille N M
AU - Kautzky-Willer, Alexandra
AU - Dunne, Fidelma
AU - Corcoy, Rosa
AU - Devlieger, Roland
AU - Simmons, David
AU - Adelantado, Juan M
AU - Damm, Peter
AU - Mathiesen, Elisabeth Reinhardt
AU - Jensen, Dorte Moeller
AU - Anderson, Lise Lotte T
AU - Lapolla, Annunziata
AU - Dalfrà, Maria G
AU - Bertolotto, Alessandra
AU - Wender-Ozegowska, Ewa
AU - Zawiejska, Agnieszka
AU - Hill, David J
AU - Snoek, Frank J
AU - DALI Consortium
PY - 2019/12/16
Y1 - 2019/12/16
N2 - PURPOSE OF REVIEW: The DALI (vitamin D and lifestyle intervention in the prevention of gestational diabetes mellitus (GDM)) study aimed to prevent GDM with lifestyle interventions or Vitamin D supplementation (1600 IU/day). This review summarizes the learnings from the DALI studies among pregnant women with a BMI ≥ 29 kg/m2.RECENT FINDINGS: Women diagnosed with GDM earlier in pregnancy had a worse metabolic profile than those diagnosed later. A combined physical activity (PA) and healthy eating (HE) lifestyle intervention improved both behaviours, limited gestational weight gain (GWG) and was cost-effective. Although GDM risk was unchanged, neonatal adiposity was reduced due to less sedentary time. Neither PA nor HE alone limited GWG or GDM risk. Fasting glucose was higher with HE only intervention, and lower with Vitamin D supplementation. Our combined intervention did not prevent GDM, but was cost-effective, limited GWG and reduced neonatal adiposity.
AB - PURPOSE OF REVIEW: The DALI (vitamin D and lifestyle intervention in the prevention of gestational diabetes mellitus (GDM)) study aimed to prevent GDM with lifestyle interventions or Vitamin D supplementation (1600 IU/day). This review summarizes the learnings from the DALI studies among pregnant women with a BMI ≥ 29 kg/m2.RECENT FINDINGS: Women diagnosed with GDM earlier in pregnancy had a worse metabolic profile than those diagnosed later. A combined physical activity (PA) and healthy eating (HE) lifestyle intervention improved both behaviours, limited gestational weight gain (GWG) and was cost-effective. Although GDM risk was unchanged, neonatal adiposity was reduced due to less sedentary time. Neither PA nor HE alone limited GWG or GDM risk. Fasting glucose was higher with HE only intervention, and lower with Vitamin D supplementation. Our combined intervention did not prevent GDM, but was cost-effective, limited GWG and reduced neonatal adiposity.
KW - Diabetes, Gestational/etiology
KW - Diet, Healthy
KW - Dietary Supplements
KW - Europe
KW - Exercise
KW - Female
KW - Healthy Lifestyle
KW - Humans
KW - Obesity/complications
KW - Pregnancy
KW - Pregnancy Outcome
KW - Randomized Controlled Trials as Topic
KW - Vitamin D/administration & dosage
U2 - 10.1007/s11892-019-1282-7
DO - 10.1007/s11892-019-1282-7
M3 - Review
C2 - 31845115
SN - 1534-4827
VL - 19
SP - 162
JO - Current Diabetes Reports
JF - Current Diabetes Reports
IS - 12
ER -